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ARRA Investments in Urologic Diseases

Public Health Burden
The burden of urologic diseases on the Nation is immense in both human and economic terms.  Urologic diseases encompass a wide scope of illnesses of the genitourinary tract, including conditions that are congenital and acquired, malignant and benign, male and female, medical and surgical.  They can occur at any point in development and life, and may be acute and self-limited or chronic and debilitating.

Lower Urinary Tract Symptoms (LUTS)/Benign Prostatic Hyperplasia (BPH)
LUTS/BPH is a common disorder that increases in severity as men age.  If left untreated, it can progress to more severe disease, including acute urinary retention and incontinence.  ARRA funding supports:
  • A study of the role of inflammation caused by interleukin-8 (IL-8) in BPH.1
  • A project to develop and test an efficient surgical tool capable of removing prostate tissue.2
Urinary Incontinence
Urinary incontinence (UI) is an enormously burdensome condition in terms of patient morbidity and health care costs that primarily, but not exclusively, affects women.  ARRA funding is supporting:
  • A study to elucidate the mechanisms of the association between obesity and UI in women, and facilitate the translational development of novel approaches to treatment and prevention.3
  • A project to test the effectiveness of combining behavioral treatment and drug therapy as a way to improve outcomes in the treatment of overactive bladder symptoms in men.4
Regenerative Medicine
Numerous bladder and lower urinary tract disorders involve associated tissue damage.  ARRA-supported research projects seek to build on early insights, and advance this clinically important field of study:
  • A study to evaluate stem cell implantation for the repair of defective tissues responsible for stress urinary incontinence.5
  • A project that will use new MRI methods to assess bladder regeneration and repair in animal models.6
Erectile Dysfunction
ED is a significant public health concern because of its prevalence among middle aged men and its strong association with diminished quality of life. ARRA-funding supports:
  • A clinical study trial of lifestyle intervention in obese men with erectile dysfunction.7
  • A project to study urinary bladder smooth muscle excitability, the associated vasculature and its regulation by nitric oxide.8
Urologic Chronic Pelvic Pain Syndromes (UCPPS)
UCPPS refers to two primary conditions, interstitial cystitis/painful bladder syndrome (IC/PBS) and chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS)—defined by lower urinary tract symptoms.  Generally no efficacious treatments exist for patients.  Several ARRA-funded grants and supplements have been awarded, including:
  • Grants to support the recruitment of a control cohort as part of the overall efforts of the Multi-disciplinary Approach to the Study of Chronic Pelvic pain (MAPP) Research Network.9
  • A project to assess pelvic organ “cross talk” between the bladder and colon in a knockout mouse to examine nerve function.10
  • A study to define the basic neurophysiological elements of bladder sensation—a condition seen in women with interstitial cystitis—in an animal model.11
  • The use of novel animal models of autoimmune prostate inflammation to understand the pathological basis for prostate pathology.12
  • A highly innovative project for delivering small molecule therapeutics to the bladder for treatment of urological diseases.13
Urologic Stones
ARRA funding has been used to support studies exploring the formation of stones in the kidney, ureters, or bladder and studies seeking to improve on existing treatment of urologic stones, including:
  • Studies of kidney physiology and tissues to glean insights into how stones and crystals form.14
  • A proposal to develop a device that can augment lithotripters (devices that emit shock waves to break up stones inside the body) so that they fire only when the stone is within the target zone.15
  • The development of approaches to enable more precise detection and localization of stones, as well as real-time targeting and stone-monitoring approaches during shock wave lithotripsy.16

  1. 1R01DK083293-01A1 -- Interleukin-8 Induced Biology in Benign Prostatic Hyperplasia -- Rowell, David R (TX)
  2. 1RC1DK087435-01 -- Surgical Laser Device Development for precise or Bulk Ablation of Urologic Tissue -- Wells, Jonathon (WA)
  3. 3K24DK080775-02S1 -- Obesity and Urinary Incontinence (OUI) -- Subak, Leslee L (CA)
  4. 1R01DK082548-01A1 -- Combined Behavioral and Drug Treatment of Overactive Bladder in Men -- Burgio, K (AL)
  5. 3SC2DK082388-02S1 -- Regeneration of the Pelvic and Urethral Supports by Muscle Derived from Stem Cells -- HO, Matthew H (CA)
  6. 3U01DK082315-02S1 -- Novel Studies of Bladder Regeneration in a Rodent Model -- Christ, George J (NC)
  7. 1U34DK083009-01A1 -- Lifestyle Intervention to Treat Erectile Dysfunction -- Wing, Rena R (RI)
  8. 3R37DK053832-11S2 -- Ca2+ Sparks and Urinary Bladder Smooth Muscle Excitability -- Nelson, Mark T (VT)
  9. 3U01DK082315-02S1, -- Multi-disciplinary Evaluation of Chronic Pelvic Pain Syndrome -- Andriole, Gerald L (MO); 3U01DK082325-02S1 -- University of Washington UCPPS Discovery Center -- Buchwald, Dedra S (WA); 3U01DK082345-02S1 -- Univ. of Michigan MAPP Research Network Discovery Site -- Clauw, Daniel J; Clemens, JQ (MI); 3U01DK082342-02S1 -- Interactive Mechanisms of Pelvic Pain -- Klumpp, David J (IL); 3U01DK082344-02S1 -- Multi-disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) -- Kreder, Karl J (IA); 3U01DK082370-02S2 -- Brain Bladder Interactions in IC/PBS -- Mayer, Emeran A; Rodriguez, Larissa (CA); 3U01DK082316-02S1 -- MAPP Research Network -- Landis, JR (PA);
  10. 3R01DK077699-03S2 -- Cross-sensitization in the Pelvis and Neurogenic Bladder -- Malykhina, Anna P (PA)
  11. 3R01DK051413-11S1 -- Quantitative Studies of Urinary Bladder Sensation -- Ness, Timothy J (AL)
  12. 1R01DK084454-01 -- Initiation and Regulation of Chronic Autoimmune Prostate Inflammation -- RATLIFF, TIMOTHY (IN)
  13. 1RC1DK087015-01 -- Targeted siRNA Nanotechnology for Intravesical Treatment of Urological Diseases -- Weiss, Robert M (CT)
  14. 5P01DK056788-09S1 -- Pathogenesis of Calcium Nephrolithiasis -- Coe, Frederic L (IL)
  15. 1RC1DK087062-01 -- Tracking Kidney Stones During Shock Wave Lithotripsy -- Cleveland, Robin O (MA)
  16. 1RC1DK086371-01 -- Improvement of Lithotripters by Ultrasound Imaging and Backscatter Techniques -- Crum, Lawrence (WA)

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