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ARRA Investments in Diagnostic Imaging

Public Health Burden
Recent innovations in diagnostic imaging technologies have led to more accurate diagnosis of disease and injury, as well as less-invasive biopsies and treatments.   A recent example is the use of image-guided interventions in the biopsy and treatment of prostate cancer, the most frequent non-dermatological cancer among U.S. males.

Image-Guided Interventions
Technologies for image-guided interventions provide new, minimally invasive procedures and will significantly impact the treatment of disease and injury. A variety of ARRA funded grants are exploring new image-guided interventions.  For example:
  • Comparative effectiveness studies of image-guided, robotic prostatectomy with standard invasive prostatectomy. 1
  • Development of novel technologies to improve the accuracy of prostate biopsy sampling, using MRI-guided approaches 2 and combined electrical impedance/ultrasound imaging approaches. 3
  • Development of a novel technology for non-invasive biopsy of bile duct cancer that uses a  micro-optical imaging device at the tip of a flexible catheter. 4
  • Comparative effectiveness studies of image-guided, robotic treatments with traditional open surgery approaches for vaginal prolapse. 5
Other Diagnostic Imaging Technologies
A variety of ARRA funded grants are exploring the development of other new diagnostic imaging technologies that promise to have a significant impact on diagnosis and treatment of many diseases.  For example:
  • Development of novel high-speed MR spectroscopic imaging technologies that can increase the sensitivity and specificity of breast cancer diagnosis. 6
  • Comparative effectiveness studies of novel non-invasive MR elastography approaches with standard invasive biopsies for detection and characterization of liver fibrosis. 7
  • Comparative effectiveness studies of novel MRI perfusion techniques with conventional cross sectional CT imaging approaches for diagnosis and characterization of liver tumors. 8
  • Development of novel techniques that can quantitatively assess the tradeoffs between diagnostic performance and radiation risk for combined PET/CT and SPECT/CT approaches. 9
  • Development of novel carbon “nanotubes” for tracking the migration of transplanted therapeutic stem cells using MRI. 10

  1. 1RC1EB011001-01 -- Effectiveness of Robotic Compared to Standard Prostatectomy for Prostate Cancer -- SANDA, MARTIN (MD)
  2. 1RC1EB010936-01 -- Robot-Assisted MRI-Guided Prostate Biopsy -- STOIANOVICI, DAN (MD)
  3. 1RC1EB011000-01 -- Electrical Property Based Image-guided Prostate Biopsy -- HALTER, RYAN J. (NH)
  4. 1RC1EB010900-01 -- Laser Endoscopy for Guided Biopsy in the Bile Duct -- SEIBEL, ERIC J (WA)
  5. 1RC1EB010649-01 -- Comparative Efficacy of Robotic vs Open Sacrocolpopexy for Vaginal Vault Prolapse -- ANGER, JENNIFER (CA)
  6. 1RC1EB010617-01 -- Volumetric Mapping of Breast Cancer Biomarkers using High-Speed MR Spectroscopic Imaging -- POSSE, STEFAN (NM)
  7. 1RC1EB010393-01 -- Comparative Effectiveness of Advanced Diagnostic Imaging for Hepatic Fibrosis -- TALWALKER, JAYANT (MN)
  8. 1RC1EB010384-01 -- Volumetric Perfusion MRI of Liver Tumors to Detect Early Response to Chemotherapy -- REEDER, SCOTT (WI)
  9. 1RC1EB010974-01 -- Quantitative Assessment of the Benefits and Risks of Clinical PET/CT and SPECT/CT -- KUPINSKI, MATTHEW (AZ)
  10. 1RC1EB010791-01 -- Gadonanotubes as New MRI Nanolabels for Stem Cell Tracking -- PERIN, EMERSON (TX)

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