Collaboration Details

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Title of Collaborative Activity:

Frequent Hemodialysis Network (FHN) Clinical Trials

Description of Collaborative Activity:

The Frequent Hemodialysis Network (FHN) is testing two different approaches to increasing dialysis at Clinical Centers in the U.S. and Canada. The FHN Daily Trial is a randomized controlled trial that randomizes 250 subjects to either conventional hemodialysis delivered for at least 2.5 hours, 3 days per week, or to more frequent hemodialysis delivered for 1.5 – 2.75 hours, 6 days per week. Subjects will be followed for 12 months. The current FHN Nocturnal Trial randomizes 250 subjects to home conventional hemodialysis delivered three days per week or to nocturnal home hemodialysis given six times per week that provides a standardized Kt/V equal to or greater than 4 and treatment equal to or longer than 6.0 hours. Due to the necessity of training for home dialysis, subjects are followed for 14 months. Two outcomes are being assessed in both trials. The first is a composite measure of change in left ventricular mass or death. The second is a composite of change in the physical health composite of the SF36 or death.

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