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Title of Collaborative Activity:

Toxicology in the 21st Century (Tox21) Program

Description of Collaborative Activity:

The Tox21 initiative, championed by the National Center for Advancing Translational Sciences (NCATS), the National Institute of Environmental Health Sciences (NIEHS), the U.S. Environmental Protection Agency (EPA), and the Food and Drug Administration (FDA), was formed to develop high-throughput screening tests that measure cellular harm caused by environmental chemicals. The goals of the Tox21 initiative are to identify patterns of compound-induced biological response in order to characterize toxicity and disease pathways, facilitate cross-species extrapolation, and model low dose extrapolation, to prioritize compounds for more extensive toxicological evaluation, and finally, to develop predictive models for biological response in humans.

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