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Title of Collaborative Activity:

HIV Prevention Trials Network feasibility study (HPTN 065)

Description of Collaborative Activity:

HPTN 065 is a feasibility study of an enhanced testing, linkage to care, and treatment approach to HIV prevention in the US, an intervention approach known as TLC-Plus. The study will involve evaluation of the feasibility of some components and the effectiveness of others. TLC-Plus uses innovative approaches, including 1) a community focus, 2) multi-component strategies that include behavioral and biomedical interventions, 3) the use of routinely reported HIV surveillance data to determine key outcomes, and 4) a partnership with local Departments of Health and the Centers for Disease Control and Prevention. This study will serve as a proof-of-concept formative study. It will provide key information that could guide the design and anticipate the costs of a future, large, randomized, community-level clinical trial of full implementation of a test-and-treat strategy in the U.S. Findings from this study could also inform test-and-treat efforts in other developed countries with epidemics similar to that in the U.S.

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