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RCDC

Project Listing by Category


Back to Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC) Click the column headings to sort project listings.
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CategoryFYFunding ICProject NumberSub Project #Project TitlePI NameOrg NameState / CountryAmount
Orphan Drug 2018 NIAMS 5R44AR061900-03 Development of a Porcine Model of Duchenne Muscular Dystrophy ROGERS, CHRISTOPHER EXEMPLAR GENETICS, LLC IA $150,613
Orphan Drug 2018 NIAID 1K22AI125474-01 Mechanisms by which insect specific flaviviruses are host restricted and preclude super-infection with pathogenic flaviviruses AUGUSTE, ALBERT VIRGINIA POLYTECHNIC INST AND ST UNIV VA $159,950
Orphan Drug 2018 NCI 5R01CA172582-05 Alpha Radioimmunotherapy for Lymphoma Treatment SANDMAIER, BRENDA FRED HUTCHINSON CANCER RESEARCH CENTER WA $634,846
Orphan Drug 2018 NINDS 5R01NS083813-05 Molecular Mechanisms Controlling Wallerian Degeneration of Axons TESSIER-LAVIGNE, MARC STANFORD UNIVERSITY CA $357,147
Orphan Drug 2018 NCI 5R01CA194783-04 Computational modeling of tumor burden by CT to advance cancer therapeutics MAITLAND, MICHAEL INOVA HEALTH CARE SERVICES VA $573,026
Orphan Drug 2018 NCI 5U01CA199221-05 Osteosarcoma: Patient Derived Xenograft Preclinical Testing GORLICK, RICHARD UNIVERSITY OF TX MD ANDERSON CAN CTR TX $136,071
Orphan Drug 2018 NCI 1K22CA214849-01 The role of the histone chaperone Chaf1b in sustaining the Hoxa9-driven AML differentiation block BLANCO, MARIO UNIVERSITY OF PENNSYLVANIA PA $191,970
Orphan Drug 2018 NCI 1K22CA216008-01 G0S2 in Chronic Myeloid Leukemia Disease Progression and Imatinib Resistance EIRING, ANNA TEXAS TECH UNIVERSITY HEALTH SCIS CENTER TX $193,030
Orphan Drug 2018 NCI 5R35CA197718-04 Dynamic Complexity of Brain Tumor Stem Cells RICH, JEREMY UNIVERSITY OF CALIFORNIA, SAN DIEGO CA $862,008
Orphan Drug 2018 NINDS 7R01NS081125-04 Aurora-A is a novel therapeutic target in glioblastoma LEHMAN, NORMAN UNIVERSITY OF LOUISVILLE KY $359,357
Orphan Drug 2018 NINDS 1R43NS100227-01A1 Nonsense Suppressing Drugs for Rett Syndrome KOZIKOWSKI, ALAN STARWISE THERAPEUTICS, LLC IL $282,726
Orphan Drug 2018 FIC 1R21TW010592-01 Combined Phone based video DOT and mobile payments for TB treatment in Cambodia YOONG, JOANNE UNIVERSITY OF SOUTHERN CALIFORNIA CA $77,237
Orphan Drug 2018 OD 1R21TW010592-01 Combined Phone based video DOT and mobile payments for TB treatment in Cambodia YOONG, JOANNE UNIVERSITY OF SOUTHERN CALIFORNIA CA $77,236
Orphan Drug 2018 NCI 5R01CA194742-03 Reolysin-based combination therapy in relapsed multiple myeloma PICHIORRI, FLAVIA BECKMAN RESEARCH INSTITUTE/CITY OF HOPE CA $574,645
Orphan Drug 2018 NCATS 5U54HD061222-14 8881 Rett-related disorders: Longitudinal studies, Biomarker and Clinical Outcome development. PERCY, ALAN UNIVERSITY OF ALABAMA AT BIRMINGHAM AL $130,588
Orphan Drug 2018 NICHD 5U54HD061222-14 8881 Rett-related disorders: Longitudinal studies, Biomarker and Clinical Outcome development. PERCY, ALAN UNIVERSITY OF ALABAMA AT BIRMINGHAM AL $88,800
Orphan Drug 2018 NINDS 5U54HD061222-14 8881 Rett-related disorders: Longitudinal studies, Biomarker and Clinical Outcome development. PERCY, ALAN UNIVERSITY OF ALABAMA AT BIRMINGHAM AL $41,788
Orphan Drug 2018 NCI 5R01CA195613-21 Molecular Mechanisms and Therapeutic Approaches to Malignant Gliomas HUNTER, TONY SALK INSTITUTE FOR BIOLOGICAL STUDIES CA $671,581
Orphan Drug 2018 NIAID 5R01AI103055-05 Innate and early B cell responses to V. cholerae HARRIS, JASON MASSACHUSETTS GENERAL HOSPITAL MA $750,907
Orphan Drug 2018 NIAID 5R01AI123341-02 Mechanisms Governing Translational Regulation During Plasmodium Transmission LINDNER, SCOTT PENNSYLVANIA STATE UNIVERSITY-UNIV PARK PA $386,419
Orphan Drug 2018 NIAID 5R01AI114685-04 Hit-to-lead discovery for sleeping sickness via industry-academic partnership POLLASTRI, MICHAEL NORTHEASTERN UNIVERSITY MA $475,385
Orphan Drug 2018 NCI 5R01CA202919-03 Mechanistic basis and therapeutic strategies for ARID1A mutation in ovarian cancer ZHANG, RUGANG WISTAR INSTITUTE PA $434,625
Orphan Drug 2018 NIGMS 5R01GM103790-03 Receptor and Carriers for Coupled Ion Transport SESSLER, JONATHAN UNIVERSITY OF TEXAS, AUSTIN TX $300,186
Orphan Drug 2018 NCI 5R01CA200624-03 Cytoplasmic Multimerization of the RNA-binding protein HuR is Oncogenic in Glioma NABORS, LOUIS UNIVERSITY OF ALABAMA AT BIRMINGHAM AL $342,804
Orphan Drug 2018 NCI 5R01CA190688-03 SON-mediated gene expression and leukemia AHN, ERIN UNIVERSITY OF SOUTH ALABAMA AL $346,556
Orphan Drug 2018 NCI 5R01CA194058-03 Painted erythrocyte carriers for therapy of acute myeloid leukemia SIMBERG, DIMITRI UNIVERSITY OF COLORADO DENVER CO $352,151
Orphan Drug 2018 NIAID 5R01AI127823-02 Drug discovery against lyssaviruses by high thoughput screening SCHNELL, MATTHIAS THOMAS JEFFERSON UNIVERSITY PA $384,375
Orphan Drug 2018 NCI 5R01CA201230-04 The role of H3K79 methylation in IDH-mutant leukemia BERNT, KATHRIN CHILDREN'S HOSP OF PHILADELPHIA PA $438,616
Orphan Drug 2018 NICHD 5R01HD086195-03 Smart targeting nano-theranostics for image-guided drug delivery to pediatric brain tumors LI, YUANPEI UNIVERSITY OF CALIFORNIA AT DAVIS CA $325,775
Orphan Drug 2018 NINDS 5R01NS099463-02 CCL3 as a Developmental Therapeutic to Enhance Brain Tumor Therapy SAMPSON, JOHN DUKE UNIVERSITY NC $347,813
Orphan Drug 2018 NIAID 5UM1AI069421-12 GHESKIO HIV Clinical Trial Unit PAPE, JEAN GHESKIO CENTER HAITI $1,037,231
Orphan Drug 2018 NINDS 5R01NS094388-02 Tissue Engineered Human Neuromuscular Junctions for Modeling Axonal Neuropathy KIM, DEOK-HO UNIVERSITY OF WASHINGTON WA $331,800
Orphan Drug 2018 NCI 5R01CA128943-10 Molecular analysis and therapeutic targeting of PI3K signaling in thyroid cancer DI CRISTOFANO, ANTONIO ALBERT EINSTEIN COLLEGE OF MEDICINE, INC NY $396,625
Orphan Drug 2018 NIAID 5R21AI127634-02 Novel Inhibitors of Cruzain and Trypanosoma brucei Cathpesin B as Potential Drug Candidates for the Treatment of African Trypanosomiasis and Chagas Disease MEEK, THOMAS TEXAS A&M AGRILIFE RESEARCH TX $189,280
Orphan Drug 2018 NCI 5R01CA193981-03 KLF9-dependent pathways in multiple myeloma drug resistance NIKIFOROV, MIKHAIL ROSWELL PARK CANCER INSTITUTE CORP NY $392,306
Orphan Drug 2018 NCI 5R01CA178393-03 Genomic Architecture of LGL Leukemia LOUGHRAN, THOMAS UNIVERSITY OF VIRGINIA VA $609,097
Orphan Drug 2018 NCI 5R01CA194090-03 Treatment of multiple myeloma using oncolytic myxoma virus BARTEE, ERIC MEDICAL UNIVERSITY OF SOUTH CAROLINA SC $341,981
Orphan Drug 2018 NIAID 5UM1AI069503-12 Terry Beirn CPCRA Clinical Trials Unit KAN, VIRGINIA GEORGE WASHINGTON UNIVERSITY DC $4,090,330
Orphan Drug 2018 NCI 5R01CA193895-03 Glutaminase Inhibitor Drug Discovery and Nanoparticle-Based Delivery for Pancreatic Cancer Therapy SLUSHER, BARBARA JOHNS HOPKINS UNIVERSITY MD $425,618
Orphan Drug 2018 NCI 5R01CA195718-03 Using genetically engineered mouse models of brain tumors to develop therapeutic nanoparticles & biomaterials HOLLAND, ERIC FRED HUTCHINSON CANCER RESEARCH CENTER WA $633,241
Orphan Drug 2018 NINDS 5R21NS099962-02 Developing novel treatment strategies for Spinocerebellar ataxia type 1 OPAL, PUNEET NORTHWESTERN UNIVERSITY AT CHICAGO IL $197,500
Orphan Drug 2018 NIAID 5UM1AI069521-12 Stellenbosch University Clinical Trials Unit (SUN-CTU) COTTON, MARK STELLENBOSCH UNIVERSITY TYGERBERG CAMPUS SO AFR $1,338,611
Orphan Drug 2018 NIAID 5UM1AI069463-12 Clinical Trials Units for NIAID Networks (UM1) SANNE, IAN WITS HEALTH CONSORTIUM (PTY), LTD SO AFR $1,084,670
Orphan Drug 2018 NCI 5R01CA194064-04 Combination Therapy of OvCA with Oligonucleotides and Photodynamic Therapy MING, XIN WAKE FOREST UNIVERSITY HEALTH SCIENCES NC $283,650
Orphan Drug 2018 NINDS 5K08NS096117-02 Next-Generation Diagnostics for Acute Encephalitis WILSON, MICHAEL UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $199,737
Orphan Drug 2018 NIA 5R01NS095969-03 TDP-43 Proteinopathy in ALS-FTD: Mechanism, Target Validation and Biomarker WONG, PHILIP JOHNS HOPKINS UNIVERSITY MD $50,625
Orphan Drug 2018 NINDS 5R01NS095969-03 TDP-43 Proteinopathy in ALS-FTD: Mechanism, Target Validation and Biomarker WONG, PHILIP JOHNS HOPKINS UNIVERSITY MD $354,375
Orphan Drug 2018 NIAID 5UM1AI069422-12 South African Medical Research Council Clinical Trials Unit (MRC CTU) RAMJEE, GITA MEDICAL RESEARCH COUNCIL OF SOUTH AFRICA SO AFR $1,084,670
Orphan Drug 2018 NIAID 5R01AI118224-03 Small-Molecule Antibiotics Targeting Siderophore Biosynthesis in M. tuberculosis TAN, DEREK SLOAN-KETTERING INST CAN RESEARCH NY $666,740
Orphan Drug 2018 NIAID 5UM1AI069530-12 Johns Hopkins University Kampala-Nanning Clinical Trial Unit FOWLER, MARY JOHNS HOPKINS UNIVERSITY MD $1,256,808
Orphan Drug 2018 NCI 5R01CA193675-03 Novel Role(s) of Nrf2 in the Growth of Post-Transplantation Cancer PAL, SOUMITRO BOSTON CHILDREN'S HOSPITAL MA $404,888
Orphan Drug 2018 NCI 5R01CA201719-03 A Novel Positron Emission Tomography Strategy for Early Detection and Treatment Monitoring of Graft-versus-host Disease GAMBHIR, SANJIV STANFORD UNIVERSITY CA $361,510
Orphan Drug 2018 NINDS 5R01NS097147-02 Pre-clinical testing of a novel immunotherapy for HTLV-induced neurologic disease JAIN, POOJA DREXEL UNIVERSITY PA $431,433
Orphan Drug 2018 NIAID 5UM1AI069469-12 CAPRISA Clinical Trials Unit for AIDS/Tuberculosis Prevention and Treatment ABDOOL KARIM, QUARRAISHA CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA SO AFR $1,287,739
Orphan Drug 2018 NIAID 5R01AI116605-03 Mechanisms of Mycobacterium Tuberculosis pH-driven Adaptation ABRAMOVITCH, ROBERT MICHIGAN STATE UNIVERSITY MI $380,510
Orphan Drug 2018 NIAID 5R01AI077538-09 The roles of polyphosphate and acidocalcisomes in Trypanosoma brucei DOCAMPO, ROBERTO UNIVERSITY OF GEORGIA GA $375,000
Orphan Drug 2018 NIAID 5R21AI121782-02 Cholera conjugates designed to prevent colonization and induce B cell memory WADE, WILLIAM DARTMOUTH COLLEGE NH $199,400
Orphan Drug 2018 NCI 5R01CA143130-08 Understanding and Enhancing T-Cell Responses to High Risk Human Papillomaviruses NAKAGAWA, MAYUMI UNIV OF ARKANSAS FOR MED SCIS AR $721,272
Orphan Drug 2018 NCI 5P30CA014089-43 8288 Molecular Genetics Research Program (Project-001) LIEBER, MICHAEL UNIVERSITY OF SOUTHERN CALIFORNIA CA $70,375
Orphan Drug 2018 NCI 5P30CA014089-43 8290 Tumor Microenvironment Research Program (Project-003) DECLERCK, YVES UNIVERSITY OF SOUTHERN CALIFORNIA CA $70,375
Orphan Drug 2018 NCI 5P30CA014089-43 8293 Gastrointestinal Cancers Research Program (Project-006) KAHN, MICHAEL UNIVERSITY OF SOUTHERN CALIFORNIA CA $70,375
Orphan Drug 2018 NCI 5R01CA189986-04 KSHV alteration of cellular metabolism LAGUNOFF, MICHAEL UNIVERSITY OF WASHINGTON WA $342,143
Orphan Drug 2018 NHLBI 5R01HL130336-03 Targeting Choline Phospholipid Metabolism in Lymphangioleiomyomatosis PRIOLO, CARMEN BRIGHAM AND WOMEN'S HOSPITAL MA $436,000
Orphan Drug 2018 NIAID 5UM1AI069438-12 IMPACTA PERU CLINICAL TRIALS UNIT LAMA, JAVIER ASOCIACION CIVIL IMPACTA SALUD Y EDUCACN PERU $1,693,877
Orphan Drug 2018 NIAID 5UM1AI069418-12 Emory- Duke- Orlando- CDC (EmDOC) Clinical Trials Unit LENNOX, JEFFREY EMORY UNIVERSITY GA $2,783,692
Orphan Drug 2018 NIAID 5UM1AI069476-11 The FIOCRUZ Therapeutic and Prevention HIV/AIDS Clinical Trials Unit GRINSZTEJN, BEATRIZ FUNDACAO OSWALDO CRUZ BRAZIL $773,601
Orphan Drug 2018 NIAID 5R01AI075045-09 Resistance of Malaria Parasites to Artemisinin-Based Therapies ROSENTHAL, PHILIP UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $516,295
Orphan Drug 2018 NCI 5R01CA182461-05 Defining the impact of clonal evolution on chronic lymphocytic leukemia WU, CATHERINE DANA-FARBER CANCER INST MA $362,378
Orphan Drug 2018 NIDDK 5R01DK066485-11 Structural Basis of KATP Channel Gating SHYNG, SHOW OREGON HEALTH & SCIENCE UNIVERSITY OR $346,500
Orphan Drug 2018 NCI 5R01CA176001-05 Mechanisms of Action for KCN1 in the Control of Uveal Melanoma Metastasis GROSSNIKLAUS, HANS EMORY UNIVERSITY GA $323,700
Orphan Drug 2018 NIAID 5UM1AI069496-12 San Francisco Bay Clinical Trials Unit BUCHBINDER, SUSAN PUBLIC HEALTH FOUNDATION ENTERPRISES CA $1,493,196
Orphan Drug 2018 NIAID 5R01AI123272-02 Development of a single-dose rabies virus vaccine MCGETTIGAN, JAMES THOMAS JEFFERSON UNIVERSITY PA $390,000
Orphan Drug 2018 NCI 5R01CA136494-10 Molecular Mechanism of Antiangiogenic Properties of Gold Nanoparticle MUKHERJEE, PRIYABRATA UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR OK $304,695
Orphan Drug 2018 NCI 5R00CA188259-04 Regulation of cancer cell metabolism and growth by the pancreatic tumor stroma SHERMAN, MARA OREGON HEALTH & SCIENCE UNIVERSITY OR $249,000
Orphan Drug 2018 NCI 5R01CA199725-03 avb6-directed molecular imaging and therapy SUTCLIFFE, JULIE UNIVERSITY OF CALIFORNIA AT DAVIS CA $488,662
Orphan Drug 2018 NCI 5R01CA202846-03 Targeted therapy of peritoneal carcinomatosis using theranostic nanoparticles YANG, LILY EMORY UNIVERSITY GA $411,268
Orphan Drug 2018 NICHD 5R01HD082127-04 Behavioral Inflexibility in IDD Outcome Measurement BOYD, BRIAN UNIV OF NORTH CAROLINA CHAPEL HILL NC $62,464
Orphan Drug 2018 NINDS 5F30NS100217-02 Mechanisms Underlying the Pathogenic Role of an α-Adducin/α2-Na/K ATPase Complex in Amyotrophic Lateral Sclerosis SMITH, SARAH WASHINGTON UNIVERSITY MO $31,208
Orphan Drug 2018 NIAID 5R01AI116943-03 A systematic analysis of small RNA interactions during RNA virus infections RICE, CHARLES ROCKEFELLER UNIVERSITY NY $706,055
Orphan Drug 2018 NIAID 5R01AI127456-02 Poxvirus manipulation of the host cell protein synthesis machinery WALSH, DEREK NORTHWESTERN UNIVERSITY AT CHICAGO IL $395,000
Orphan Drug 2018 NINDS 2R37NS057553-12 Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1 GAO, FEN-BIAO UNIV OF MASSACHUSETTS MED SCH WORCESTER MA $594,625
Orphan Drug 2018 NIAID 5R01AI056312-12 Function of antimalarial drug resistance proteins ROEPE, PAUL GEORGETOWN UNIVERSITY DC $413,757
Orphan Drug 2018 NIAID 5UM1AI069453-12 KARABELO Clinical Trials Unit for NIAID Networks GRAY, GLENDA WITS HEALTH CONSORTIUM (PTY), LTD SO AFR $1,461,054
Orphan Drug 2018 NIAID 5R01AI113266-03 Closing the Gaps on Buruli Ulcer Diagnosis, Treatment, and Prevention NUERMBERGER, ERIC JOHNS HOPKINS UNIVERSITY MD $881,258
Orphan Drug 2018 NIAID 5R01AI122753-03 Systematic evaluation of B. pertussis ACT’s role as a protective antigen MAYNARD, JENNIFER UNIVERSITY OF TEXAS, AUSTIN TX $375,718
Orphan Drug 2018 NIAID 5R21AI128175-02 Toward an Pan-lyssavirus vaccine SCHNELL, MATTHIAS THOMAS JEFFERSON UNIVERSITY PA $234,000
Orphan Drug 2018 NCI 5R01CA195519-03 Image-guided irradiation safely intensifies HSCT regimen for refractory leukemia FORMAN, STEPHEN BECKMAN RESEARCH INSTITUTE/CITY OF HOPE CA $238,425
Orphan Drug 2018 NCI 5R01CA201184-03 Biologic and Therapeutic Significance of miR-155 in AML MARCUCCI, GUIDO BECKMAN RESEARCH INSTITUTE/CITY OF HOPE CA $549,553
Orphan Drug 2018 NIGMS 5R01GM107465-04 Molecular principles of translation termination KOROSTELEV, ANDREI UNIV OF MASSACHUSETTS MED SCH WORCESTER MA $322,438
Orphan Drug 2018 NHLBI 5R01HL125228-04 Mineralocorticoid receptor and abdominal aortic aneurysm GONG, MING UNIVERSITY OF KENTUCKY KY $519,619
Orphan Drug 2018 NIGMS 5R01GM099836-06 Defining the mechanistic basis of a prion disaggregase SHORTER, JAMES UNIVERSITY OF PENNSYLVANIA PA $339,308
Orphan Drug 2018 NCI 5R01CA211125-02 Regulation of lung cancer metastasis through transcriptional control of the Golgi apparatus KURIE, JONATHAN UNIVERSITY OF TX MD ANDERSON CAN CTR TX $376,867
Orphan Drug 2018 NCI 5R01CA190617-04 Itraconazole Analogues to Treat Medulloblastoma HADDEN, MATTHEW UNIVERSITY OF CONNECTICUT STORRS CT $382,211
Orphan Drug 2018 NCI 5P30CA014195-45 7749 PL Mouse HUNTER, TONY SALK INSTITUTE FOR BIOLOGICAL STUDIES CA $43,092
Orphan Drug 2018 NINDS 5R35NS097263-02 Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease GITLER, AARON STANFORD UNIVERSITY CA $1,027,273
Orphan Drug 2018 NCI 5P30CA016058-42 5094 Clinical Protocol and Data Management (Core 017) DEVINE, STEVEN OHIO STATE UNIVERSITY OH $491,214
Orphan Drug 2018 NCI 5P30CA016058-42 5098 Leukemia Research Program (LR) BYRD, JOHN OHIO STATE UNIVERSITY OH $65,564
Orphan Drug 2018 NINDS 5R35NS097275-02 Molecular Genetic Insight into Neurodegenerative Disease from Drosophila BONINI, NANCY UNIVERSITY OF PENNSYLVANIA PA $703,113
Orphan Drug 2018 NIAID 5R21AI127635-02 Identification of preclinical drug candidates for the treatment of schistosomiasis WILLIAMS, DAVID RUSH UNIVERSITY MEDICAL CENTER IL $169,545
Orphan Drug 2018 NIAID 5R21AI118351-02 Role of M. tuberculosis error-prone DNA polymerase DnaE2 in mutagenesis and drug resistance MCDONOUGH, KATHLEEN WADSWORTH CENTER NY $203,062
Orphan Drug 2018 NINDS 5K08NS096219-02 Global AAV gene therapy of Tay-Sachs disease in sheep. EDWARDS, HEATHER AUBURN UNIVERSITY AT AUBURN AL $169,128
Orphan Drug 2018 NIAID 5R01AI123245-02 Community-directed vector control to enhance mass drug administration for onchocerciasis elimination in Africa UNNASCH, THOMAS UNIVERSITY OF SOUTH FLORIDA FL $520,781
Orphan Drug 2018 NCI 5R01CA042324-31 Astatine And Iodine Radiolabeled Monoclonal Antibodies ZALUTSKY, MICHAEL DUKE UNIVERSITY NC $455,654
Orphan Drug 2018 NIDDK 5R01DK105434-03 Investigating Autophagy in GSD-Ia KOEBERL, DWIGHT DUKE UNIVERSITY NC $320,889
Orphan Drug 2018 NINDS 5K08NS099427-02 Targeting ATRX-Deficient Pediatric GBM KOSCHMANN, CARL UNIVERSITY OF MICHIGAN AT ANN ARBOR MI $163,263
Orphan Drug 2018 NCI 5P30CA016086-42 8610 Animal Models WEISSMAN, BERNARD UNIV OF NORTH CAROLINA CHAPEL HILL NC $312,517
Orphan Drug 2018 NCI 5P30CA016086-42 8627 EARLY PHASE CLINICAL RESEARCH SUPPORT (Core 020) DEES, ELIZABETH UNIV OF NORTH CAROLINA CHAPEL HILL NC $287,365
Orphan Drug 2018 NCI 5P30CA016086-42 8629 Immunology Research Program (Program 2) SERODY, JONATHAN UNIV OF NORTH CAROLINA CHAPEL HILL NC $39,437
Orphan Drug 2018 NCI 5R01CA175380-05 FoxM1 in liver cancer. RAYCHAUDHURI, PRADIP UNIVERSITY OF ILLINOIS AT CHICAGO IL $405,146
Orphan Drug 2018 NCI 5R01CA157490-08 Investigating the Role of Autophagy in Pancreatic Cancer Radiation Resistance KIMMELMAN, ALEC NEW YORK UNIVERSITY SCHOOL OF MEDICINE NY $402,563
Orphan Drug 2018 NIAID 5R01AI128215-02 A systems analysis of drug tolerance in Mycobacterium tuberculosis BALIGA, NITIN INSTITUTE FOR SYSTEMS BIOLOGY WA $912,707
Orphan Drug 2018 NIDDK 5F30DK101230-04 Characterizing Isu Scaffolding Protein and ISC Multiprotein Complex Structure and DZUL, STEPHEN WAYNE STATE UNIVERSITY MI $49,524
Orphan Drug 2018 NIDDK 5R01DK103854-03 U2AF1 mutations in myelodysplastic syndromes: from mechanism to therapy BRADLEY, ROBERT FRED HUTCHINSON CANCER RESEARCH CENTER WA $396,105
Orphan Drug 2018 NIMH 5R01MH106656-03 Disrupted auditory cortical plasticity and behavior in a model of Rett syndrome SHEA, STEPHEN COLD SPRING HARBOR LABORATORY NY $518,964
Orphan Drug 2018 NIAID 5F30AI118342-03 Intercellular spread of Burkholderia and novel therapeutic strategies BULTERYS, PHILIP UNIVERSITY OF CALIFORNIA LOS ANGELES CA $44,770
Orphan Drug 2018 NIAID 5R21AI127622-02 Targeting Plasmodium apicoplast DNA replication for the treatment and prevention of malaria NELSON, SCOTT IOWA STATE UNIVERSITY IA $195,919
Orphan Drug 2018 NCI 5R01CA158073-07 The Role of ATM in Suppression of Lymphomas ZHA, SHAN COLUMBIA UNIVERSITY HEALTH SCIENCES NY $380,000
Orphan Drug 2018 NCI 5R01CA142779-08 PD-1/PD-L1 modulation in cancer therapy PARDOLL, DREW JOHNS HOPKINS UNIVERSITY MD $488,332
Orphan Drug 2018 NCI 5R01CA196631-03 A network platform to connect drug response and prognosis phenotypes for cancers LI, HU MAYO CLINIC ROCHESTER MN $395,911
Orphan Drug 2018 NHLBI 5R01HL130533-03 Identifying Therapeutic Targets for RNA Splicing-Related Cardiomyopathy CONKLIN, BRUCE J. DAVID GLADSTONE INSTITUTES CA $456,506
Orphan Drug 2018 NCI 5P30CA016042-43 6733 Tumor Immunology GASSON, JUDITH UNIVERSITY OF CALIFORNIA LOS ANGELES CA $46,785
Orphan Drug 2018 NCI 5P30CA016042-43 6743 Early Phase Clinical Research Support GASSON, JUDITH UNIVERSITY OF CALIFORNIA LOS ANGELES CA $106,469
Orphan Drug 2018 NIAID 5R21AI128311-02 A novel nanobody with good druggability to prevent and treat MERS-CoV infection DU, LANYING NEW YORK BLOOD CENTER NY $219,500
Orphan Drug 2018 NIAID 5R21AI128517-02 Novel antitrypanosomal alkaloids for Chagas disease TAN, DEREK SLOAN-KETTERING INST CAN RESEARCH NY $244,800
Orphan Drug 2018 NIAID 5R21AI127594-02 Lead optimization of agents targeting multiple kinetoplastid parasites POLLASTRI, MICHAEL NORTHEASTERN UNIVERSITY MA $266,948
Orphan Drug 2018 NIAID 5R21AI127505-02 Development of Gallinamide A-Inspired Agents for the Treatment of Chagas’ Disease GERWICK, WILLIAM UNIVERSITY OF CALIFORNIA, SAN DIEGO CA $227,593
Orphan Drug 2018 NCI 5R03CA212800-02 Advancing Treatments for Pediatric Craniopharyngioma (ATPC): Preliminary Assessment of the Cyst Fluid Inflammatory Milieu HANKINSON, TODD UNIVERSITY OF COLORADO DENVER CO $77,750
Orphan Drug 2018 NCI 5R01CA204979-02 Mechanisms of inv(16) acute myeloid leukemia CASTILLA, LUCIO UNIV OF MASSACHUSETTS MED SCH WORCESTER MA $436,263
Orphan Drug 2018 NIDDK 5R01DK107716-03 Regulation of the telomerase RNA component in hematopoiesis AGARWAL, SUNEET BOSTON CHILDREN'S HOSPITAL MA $398,250
Orphan Drug 2018 NIGMS 5R01GM067871-15 Structural Requirements for Sterol 14alpha-Demethylases LEPESHEVA, GALINA VANDERBILT UNIVERSITY TN $409,128
Orphan Drug 2018 NHLBI 5R01HL070227-15 HL-Development and Pharmacology of novel lipidic rAHF and biotherapeutics BALU-IYER, SATHY STATE UNIVERSITY OF NEW YORK AT BUFFALO NY $395,244
Orphan Drug 2018 NHLBI 5R01HL131143-03 Development of a gene therapy approach to treat acute lung injury using a preclinical, large animal model DEAN, DAVID UNIVERSITY OF ROCHESTER NY $759,156
Orphan Drug 2018 NIAID 5R01AI128862-02 Biosynthesis and medicinal chemistry of the capuramycin antimycobacterial antibiotics VAN LANEN, STEVEN UNIVERSITY OF KENTUCKY KY $200,000
Orphan Drug 2018 NCI 5R01CA188134-02 Nrf2 Regulation of Ductal Pancreatic Cancer Etiology and Treatment Response TUVESON, DAVID COLD SPRING HARBOR LABORATORY NY $615,683
Orphan Drug 2018 NIGMS 5R01GM116823-03 Neutrophil-mediated Drug Delivery WANG, ZHENJIA WASHINGTON STATE UNIVERSITY WA $339,750
Orphan Drug 2018 NICHD 5R21HD087760-02 Targeting SHP2 phosphatase for chemoprevention of leukemic progression in Noonan syndrome QU, CHENG-KUI EMORY UNIVERSITY GA $234,000
Orphan Drug 2018 NHLBI 5R01HL130871-03 Development of highly efficient factor VIII mini-gene therapy XIAO, WEIDONG TEMPLE UNIV OF THE COMMONWEALTH PA $482,625
Orphan Drug 2018 NIAMS 5R01AR066003-04 MKP5 in Dystrophic Muscle Disease BENNETT, ANTON YALE UNIVERSITY CT $392,351
Orphan Drug 2018 NIAID 5R21AI127581-02 Parasite-specific proteasome inhibitors to combat multi-drug resistant malaria BOGYO, MATTHEW STANFORD UNIVERSITY CA $215,097
Orphan Drug 2018 NIAID 5R21AI128737-02 Rapid development of replication-controlled vaccinia virus vectors for vaccines and therapeutics with single or double safety features VERARDI, PAULO UNIVERSITY OF CONNECTICUT STORRS CT $193,993
Orphan Drug 2018 NCI 5R01CA055349-24 Mechanisms of action of a TCR-like antibody to WT1 SCHEINBERG, DAVID SLOAN-KETTERING INST CAN RESEARCH NY $384,667
Orphan Drug 2018 NCI 5R01CA174861-05 Novel Theranostics for Pancreatic Cancer DAVYDOVA, JULIA UNIVERSITY OF MINNESOTA MN $319,031
Orphan Drug 2018 NCI 5R01CA196215-03 Systemic Therapy with Infectivity-Selective Oncolytic Adenovirus for PDAC YAMAMOTO, MASATO UNIVERSITY OF MINNESOTA MN $351,132
Orphan Drug 2018 NCI 5R01CA205633-02 Inhibition of Oral Tumorigenesis by Antitumor B YOU, MING MEDICAL COLLEGE OF WISCONSIN WI $504,001
Orphan Drug 2018 NCI 5R01CA211337-02 Molecular Imaging Markers for Glutaminolysis in Breast Cancer MANKOFF, DAVID UNIVERSITY OF PENNSYLVANIA PA $382,319
Orphan Drug 2018 NCI 5R01CA211681-02 USP7 inhibitors for the treatment of multiple myeloma BUHRLAGE, SARA DANA-FARBER CANCER INST MA $504,721
Orphan Drug 2018 NCI 5R01CA212649-02 Personalized vaccine for patients with AML AVIGAN, DAVID BETH ISRAEL DEACONESS MEDICAL CENTER MA $721,179
Orphan Drug 2018 NICHD 5UG1HD083166-04 Collaborative Research to Validate Biomarkers of Pediatric ARDS MCQUILLEN, PATRICK UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $272,217
Orphan Drug 2018 NICHD 5R01HD064727-08 SLOS and Neuronal Oxidative Stress PORTER, NED VANDERBILT UNIVERSITY TN $432,819
Orphan Drug 2018 NHLBI 5R01HL135114-02 Clinical and mechanistic role of HDGF in pulmonary hypertension EVERETT, ALLEN JOHNS HOPKINS UNIVERSITY MD $638,631
Orphan Drug 2018 NIAID 5R21AI127489-02 Treatment and Prevention of Systemic Candidiasis NOBLE, SUZANNE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $229,936
Orphan Drug 2018 NIAID 5R01AI123024-03 Novel methods of pharmacologic monitoring for multidrug resistant tuberculosis treatment in the setting of HIV infection METCALFE, JOHN UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $696,561
Orphan Drug 2018 NIAID 5R01AI127711-02 Modulation of Host Cell Environment by Mycobacterial PE/PPE Proteins LEE, SUNHEE DUKE UNIVERSITY NC $553,074
Orphan Drug 2018 NCI 5R01CA203348-03 Blocking NK cell shedding of CD16a to increase cancer cell killing WALCHECK, BRUCE UNIVERSITY OF MINNESOTA MN $447,909
Orphan Drug 2018 NCI 5R01CA212600-02 Targeting HuR to improve a synthetic lethal therapy for pancreatic cancer BRODY, JONATHAN THOMAS JEFFERSON UNIVERSITY PA $372,748
Orphan Drug 2018 NCI 5R01CA211016-02 Immune Impact on Cancer Chemoresistance ZOU, WEIPING UNIVERSITY OF MICHIGAN AT ANN ARBOR MI $611,871
Orphan Drug 2018 NEI 5R01EY024249-04 A High Content Screening Approach for the Retinal Degenerative Diseases BERLINICKE, CYNTHIA JOHNS HOPKINS UNIVERSITY MD $405,000
Orphan Drug 2018 NIA 5R01AG052496-02 Emotion network dysfunction and decline in early frontotemporal dementia STURM, VIRGINIA UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $551,852
Orphan Drug 2018 NIAID 5R01AI085051-09 Drug Resistance in HCV NS3/4A - Inhibitor binding versus substrate recognition SCHIFFER, CELIA UNIV OF MASSACHUSETTS MED SCH WORCESTER MA $588,464
Orphan Drug 2018 NIAID 5R01AI123244-03 Mucosal Vaccines for Brucellosis PASCUAL, DAVID UNIVERSITY OF FLORIDA FL $436,758
Orphan Drug 2018 NCI 5R01CA169784-05 Genetic Dissection of Acute Myeloid Leukemia. AIFANTIS, IANNIS NEW YORK UNIVERSITY SCHOOL OF MEDICINE NY $355,993
Orphan Drug 2018 NCI 5R01CA196263-03 Peripherally-restricted cannabinoids for cancer and chemotherapy-induced pain SCHMIDT, BRIAN NEW YORK UNIVERSITY NY $492,705
Orphan Drug 2018 NIDCR 5R21DE025920-02 Comprehensive Identification of FXR1 Targets Using pSILAC-BONCAT Proteomics PALANISAMY, VISWANATHAN MEDICAL UNIVERSITY OF SOUTH CAROLINA SC $186,875
Orphan Drug 2018 NHLBI 5R01HL132153-02 Functional Impact of Col18a1/Endostatin Variants in PAH DAMICO, RACHEL JOHNS HOPKINS UNIVERSITY MD $644,325
Orphan Drug 2018 NIDCR 5F31DE026682-02 Immunomodulatory Nanoparticles in Combination with Immune Checkpoint Inhibitors for the Systemic Treatment of Immunosuppressive HPV Associated Oropharyngeal Cancer NEWTON, JARED BAYLOR COLLEGE OF MEDICINE TX $45,324
Orphan Drug 2018 NIAID 5R21AI128480-02 Chemical genetic screening to identify synergistic inhibitors of malaria parasite cell cycle regulators DURAISINGH, MANOJ HARVARD SCHOOL OF PUBLIC HEALTH MA $199,010
Orphan Drug 2018 NCI 5R01CA065823-22 Characterizing the landscape of resistance and persistence mechanisms in CML DRUKER, BRIAN OREGON HEALTH & SCIENCE UNIVERSITY OR $329,175
Orphan Drug 2018 NCI 5R01CA181658-04 MRI-Monitored Delivery of Sorafenib-Eluting Microspheres to Liver Tumors LARSON, ANDREW NORTHWESTERN UNIVERSITY AT CHICAGO IL $451,626
Orphan Drug 2018 NCI 5R01CA204446-02 Antivascular ultrasound therapy of primary liver neoplasia SEHGAL, CHANDRA UNIVERSITY OF PENNSYLVANIA PA $415,179
Orphan Drug 2018 NCI 5R21CA205564-02 A new class of CSF-1R radioligands for monitoring glioblastoma progression and therapy CHIN, FREDERICK STANFORD UNIVERSITY CA $171,060
Orphan Drug 2018 NCI 5R01CA204136-02 Credentialing murine models for glioblastoma preclinical drug development MILLER, CHRISTOPHER UNIV OF NORTH CAROLINA CHAPEL HILL NC $605,422
Orphan Drug 2018 NCATS 1UG3TR002151-01 Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screening LEONG, KAM COLUMBIA UNIVERSITY HEALTH SCIENCES NY $1,177,110
Orphan Drug 2018 NIAID 5R01AI118389-04 Vaccines Against Botulism BARBIERI, JOSEPH MEDICAL COLLEGE OF WISCONSIN WI $585,553
Orphan Drug 2018 NHLBI 5R01HL132213-02 Role of Cardiac Troponin in Health and Disease DAVIS, JONATHAN OHIO STATE UNIVERSITY OH $377,595
Orphan Drug 2018 NIAID 5R21AI121993-02 Multifactor mRNA Mediated T Cell Reprogramming for Systemic Lupus Erythematosus KATZ, SAMUEL YALE UNIVERSITY CT $167,500
Orphan Drug 2018 NIAID 5R21AI127582-02 A Systems Biology Approach for Targeted Drug Discovery for Leishmaniasis IBBA, MICHAEL OHIO STATE UNIVERSITY OH $205,141
Orphan Drug 2018 NIAID 5R21AI127591-02 Development of Novel Therapeutics for Leishmaniasis LANDFEAR, SCOTT OREGON HEALTH & SCIENCE UNIVERSITY OR $189,589
Orphan Drug 2018 NIAID 5R21AI123876-02 Development of a method for visual detection of Mycobacterium tuberculosis complex GERASIMOVA, YULIA UNIVERSITY OF CENTRAL FLORIDA FL $177,776
Orphan Drug 2018 NIAID 5R21AI127503-02 Targeting trypanosomatid deoxyhypusine synthase PHILLIPS, MARGARET UT SOUTHWESTERN MEDICAL CENTER TX $202,500
Orphan Drug 2018 NIAID 5R01AI127654-02 Generation of Robust Resident Memory T cells in Barrier Tissues through Skin Vaccination KUPPER, THOMAS BRIGHAM AND WOMEN'S HOSPITAL MA $1,010,181
Orphan Drug 2018 NCI 5R01CA120813-12 Modulation of Microglia and T Cell Interactions in Malignant Glioma HEIMBERGER, AMY UNIVERSITY OF TX MD ANDERSON CAN CTR TX $288,000
Orphan Drug 2018 NCI 5R01CA183444-05 Molecular Evaluation of Targeted Therapies in Lymphoid Malignancies BYRD, JOHN OHIO STATE UNIVERSITY OH $501,285
Orphan Drug 2018 NCI 5R01CA142874-08 Targeting PML for Leukemia Therapy PANDOLFI, PIER PAOLO BETH ISRAEL DEACONESS MEDICAL CENTER MA $457,619
Orphan Drug 2018 NCI 5R01CA184088-04 Liposomal Doxorubicin and Pluronic Combination for Cancer Therapy KABANOV, ALEXANDER UNIV OF NORTH CAROLINA CHAPEL HILL NC $344,549
Orphan Drug 2018 NIBIB 5R01EB019458-04 Pre-clinical quantitation of ovarian cancer tumor burden using Magnetic Particle Imaging and non-dilutive cell labeling CONOLLY, STEVEN UNIVERSITY OF CALIFORNIA BERKELEY CA $462,841
Orphan Drug 2018 NHLBI 5K08HL130592-02 Functional Characterization of Phosphodiesterase 1 in Single Ventricle Heart Disease NAKANO, STEPHANIE UNIVERSITY OF COLORADO DENVER CO $165,240
Orphan Drug 2018 NHLBI 5R01HL134905-02 Anastrozole in Pulmonary Arterial Hypertension (AIPH2) - CCC (Lead) KAWUT, STEVEN UNIVERSITY OF PENNSYLVANIA PA $1,114,479
Orphan Drug 2018 NINDS 5K08NS099484-02 Leveraging Temozolomide to Improve Treatment Efficacy of Immune Checkpoint Blockade in Glioblastoma RAHMAN, MARYAM UNIVERSITY OF FLORIDA FL $181,980
Orphan Drug 2018 NCI 5R03CA212877-02 Tumor Molecular Profiling and Response to Immunotherapy in Advanced Biliary Cancers KELLEY, R. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $79,250
Orphan Drug 2018 NIAID 5R21AI128362-02 Structure- and ligand-based design of new IspD-targeting antimalarials CARLIER, PAUL VIRGINIA POLYTECHNIC INST AND ST UNIV VA $185,600
Orphan Drug 2018 NIGMS 5SC3GM112543-04 Aberrant Epigenetic Repression in Esophageal Malignancy LIN, CHIN-HSING UNIVERSITY OF TEXAS SAN ANTONIO TX $110,250
Orphan Drug 2018 NIGMS 5R01GM079656-11 Comparative genomics of protein structure and function LICHTARGE, OLIVIER BAYLOR COLLEGE OF MEDICINE TX $396,958
Orphan Drug 2018 NCI 5K25CA201545-02 Development of microfluidic blood-brain tumor barrier model to screen chemotherapeutic strategies for breast cancer brain metastases LEE, WON JAE STANFORD UNIVERSITY CA $157,167
Orphan Drug 2018 NIAID 5R21AI128097-02 Development of Human Broadly Neutralizing Monoclonal Antibodies Against New World Arenaviruses​ MARTINEZ-SOBRIDO, LUIS UNIVERSITY OF ROCHESTER NY $277,659
Orphan Drug 2018 NIAID 5R21AI123501-02 Mechanism-based targeting of bacterial topoisomerases MAIZELS, NANCY UNIVERSITY OF WASHINGTON WA $243,323
Orphan Drug 2018 NCI 5R00CA183914-05 A Novel Oncogenic Role for Cdc20 Implications in Adult T Cell Leukemia Treatment WAN, LIXIN H. LEE MOFFITT CANCER CTR & RES INST FL $148,607
Orphan Drug 2018 NCI 5R01CA175772-05 Targeting tumor-stromal interaction for pancreatic cancer therapy SINGH, AJAY UNIVERSITY OF SOUTH ALABAMA AL $314,363
Orphan Drug 2018 NCI 5R01CA195503-04 Nanoparticle Modified Human Fat Derived Mesenchymal Stem Cells for Brain Cancer (Change of Organization Application) QUINONES-HINOJOSA, ALFREDO MAYO CLINIC JACKSONVILLE FL $363,623
Orphan Drug 2018 NCI 5R01CA190498-04 gp130 as a novel therapeutic target in ovarian cancer NEAMATI, NOURI UNIVERSITY OF MICHIGAN AT ANN ARBOR MI $376,320
Orphan Drug 2018 NCI 5R01CA172724-04 Novel Strategies to Target Leukemia-Stromal Interactions PELICANO, HELENE UNIVERSITY OF TX MD ANDERSON CAN CTR TX $366,000
Orphan Drug 2018 NCI 5R01CA213448-02 Immuno-PET imaging of high-grade neuroendocrine lung tumors using 89Zr-rovalpituzumab, a DLL3-targeting monoclonal antibody POIRIER, JOHN SLOAN-KETTERING INST CAN RESEARCH NY $699,927
Orphan Drug 2018 NCI 5R01CA211175-02 Averting recurrent and resistant ovarian tumors WANG, QIEN OHIO STATE UNIVERSITY OH $451,109
Orphan Drug 2018 NHLBI 5R01HL031823-28 Heme synthesis, use and trafficking during erythropoiesis ABKOWITZ, JANIS UNIVERSITY OF WASHINGTON WA $415,875
Orphan Drug 2018 NCI 5R01CA142665-08 Glucocorticoids in Lymphoblastic Leukemia RELLING, MARY ST. JUDE CHILDREN'S RESEARCH HOSPITAL TN $487,994
Orphan Drug 2018 NIAID 5R01AI093380-06 Malaria Topoisomerase inhibitors RATHOD, PRADIPSINH UNIVERSITY OF WASHINGTON WA $490,036
Orphan Drug 2018 NIAID 5R21AI128090-02 Engineered Dengue EDIIIs as Broad Immunogens LAI, JONATHAN ALBERT EINSTEIN COLLEGE OF MEDICINE, INC NY $254,193
Orphan Drug 2018 NCI 5P30CA014236-44 5328 Neuro-Oncology Research Program KASTAN, MICHAEL DUKE UNIVERSITY NC $40,785
Orphan Drug 2018 NCI 5P30CA014236-44 5329 Women's Cancer Research Program KASTAN, MICHAEL DUKE UNIVERSITY NC $36,366
Orphan Drug 2018 NCI 5P30CA014236-44 5330 Hematologic Malignancies and Cellular Therapies Research Program KASTAN, MICHAEL DUKE UNIVERSITY NC $40,785
Orphan Drug 2018 NCI 5P30CA014236-44 5331 Solid Tumor Therapeutics Research Program KASTAN, MICHAEL DUKE UNIVERSITY NC $40,785
Orphan Drug 2018 NIAID 5R01AI119022-04 Structure and mechanism of the ESX secretion system from pathogenic mycobacteria KOROTKOV, KONSTANTIN UNIVERSITY OF KENTUCKY KY $376,250
Orphan Drug 2018 NCI 5R01CA207401-02 Increasing HPV vaccine uptake in community-based pediatric practices HULL, PAMELA VANDERBILT UNIVERSITY MEDICAL CENTER TN $565,206
Orphan Drug 2018 NCI 5P30CA023108-39 5370 Cancer Imaging & Radiobiology (CIR) PAULSEN, KEITH DARTMOUTH COLLEGE NH $72,840
Orphan Drug 2018 NCI 5P30CA023108-39 5371 Immunology & Cancer Immunotherapy (ICI) SENTMAN, CHARLES DARTMOUTH COLLEGE NH $72,409
Orphan Drug 2018 NIAMS 5R03AR068118-03 The Cytosolic Nucleic Acid-Sensing Pathway and Skin Antiviral Innate Immunity DENG, LIANG SLOAN-KETTERING INST CAN RESEARCH NY $85,700
Orphan Drug 2018 NIAAA 5P50AA011999-20 8467 Functional Dissection of EtOH-med Self-renew of Liver Tumor-Int Cells via TLR4 MACHIDA, KEIGO UNIVERSITY OF SOUTHERN CALIFORNIA CA $203,571
Orphan Drug 2018 NIAID 5R21AI129531-02 Discovering host factors impacting ZIKV infection via forward genetic screens BATES, PAUL UNIVERSITY OF PENNSYLVANIA PA $195,138
Orphan Drug 2018 NIAID 5R01AI104488-05 A Nurse Case Management Intervention to Improve MDR-TB/HIV Coinfection Outcomes FARLEY, JASON JOHNS HOPKINS UNIVERSITY MD $1
Orphan Drug 2018 NIAID 5R01AI114873-04 ZAP isoforms in innate immunity-the long, the short and the extra-long of it all MACDONALD, MARGARET ROCKEFELLER UNIVERSITY NY $423,750
Orphan Drug 2018 NIAID 5R01AI127724-02 Development of Selective Ribosomal P-site Inhibitors LOOPER, RYAN UNIVERSITY OF UTAH UT $379,792
Orphan Drug 2018 NHLBI 5R00HL118157-05 Regulation of Erythroid Terminal Differentiation by Long Noncoding RNAs HU, WENQIAN MAYO CLINIC ROCHESTER MN $249,000
Orphan Drug 2018 NINDS 5R01NS091575-03 Targeting the Ubiquitin Proteasome System to Treat Spinal Muscular Atrophy BURNETT, BARRINGTON HENRY M. JACKSON FDN FOR THE ADV MIL/MED MD $303,692
Orphan Drug 2018 NIAID 5K08AI127908-02 Translational modeling of individual- and population-level outcomes of novel tuberculosis drug regimens KENDALL, EMILY JOHNS HOPKINS UNIVERSITY MD $194,681
Orphan Drug 2018 NIAID 5R01AI114674-04 The Consequences of Reinfection with M. tuberculosis FLYNN, JOANNE UNIVERSITY OF PITTSBURGH AT PITTSBURGH PA $744,863
Orphan Drug 2018 NCI 5P30CA006516-53 5399 Program 4: Leukemia EBERT, BENJAMIN BRIGHAM AND WOMEN'S HOSPITAL MA $74,743
Orphan Drug 2018 NCI 5P30CA006516-53 5400 Program 6: Lymphoma and Myeloma SHIPP, MARGARET DANA-FARBER CANCER INST MA $73,653
Orphan Drug 2018 NCI 5P30CA006516-53 5405 Program 11: Cancer Immunology SHARPE, ARLENE HARVARD MEDICAL SCHOOL MA $77,721
Orphan Drug 2018 NCI 5P30CA006516-53 5409 Program 30: Neuro-Oncology STILES, CHARLES DANA-FARBER CANCER INST MA $75,340
Orphan Drug 2018 NCI 5P30CA006516-53 5410 Program 32: Gastrointestinal Malignancies FUCHS, CHARLES DANA-FARBER CANCER INST MA $73,899
Orphan Drug 2018 NCI 5P30CA006516-53 5413 Program 52: Kidney Cancer MCDERMOTT, DAVID BETH ISRAEL DEACONESS MEDICAL CENTER MA $93,630
Orphan Drug 2018 NCI 5R01CA187219-03 Peptide vaccine immunotherapy for children with recurrent low-grade astrocytomas POLLACK, IAN UNIVERSITY OF PITTSBURGH AT PITTSBURGH PA $352,786
Orphan Drug 2018 NCI 5R01CA213423-02 High-frequency Irreversible Electroporation (H-FIRE) combinatorial GBM treatment DAVALOS, RAFAEL VIRGINIA POLYTECHNIC INST AND ST UNIV VA $359,874
Orphan Drug 2018 NCI 5R01CA213278-02 Reprogramming Tumor Microenvironment by Nanoparticle MUKHERJEE, PRIYABRATA UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR OK $338,550
Orphan Drug 2018 NIGMS 5R01GM113236-04 Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis BESNER, GAIL RESEARCH INST NATIONWIDE CHILDREN'S HOSP OH $284,050
Orphan Drug 2018 NHLBI 5R01HL079118-12 Roles of Mre11 in Lymphocyte Development and DNA Repair FERGUSON, DAVID UNIVERSITY OF MICHIGAN AT ANN ARBOR MI $380,944
Orphan Drug 2018 NHLBI 5UG1HL135665-02 Pediatric Heart Network Regents of the University of Michigan GOLDBERG, CAREN UNIVERSITY OF MICHIGAN AT ANN ARBOR MI $340,964
Orphan Drug 2018 NCI 5R01CA150190-07 Targeting Pancreatic Cancer Using Peptide Chemistry: From Bench to Bedside MUKHOPADHYAY, DEBABRATA MAYO CLINIC JACKSONVILLE FL $586,058
Orphan Drug 2018 NCI 5R01CA151354-07 Biological Validation of Candidate Myeloma Driver Genes JANZ, SIEGFRIED UNIVERSITY OF IOWA IA $590,938
Orphan Drug 2018 NCI 5R01CA211646-02 Assays to Identify Prostate Cancer Therapeutics Targeting Antizyme Inhibitor ZETTER, BRUCE BOSTON CHILDREN'S HOSPITAL MA $411,481
Orphan Drug 2018 NIBIB 5R00EB016690-05 Role of cerebrospinal fluid dynamics in brain drug delivery SY, JAY RUTGERS, THE STATE UNIV OF N.J. NJ $237,529
Orphan Drug 2018 NICHD 5R01HD084500-04 Markers of Disease Progression in MECP2 Duplication Syndrome PETERS, SARIKA VANDERBILT UNIVERSITY MEDICAL CENTER TN $326,652
Orphan Drug 2018 NIAID 5R21AI127639-02 Novel Therapeutics for Treatment of River Blindness and Lymphatic Filariasis SAKANARI, JUDY UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $195,658
Orphan Drug 2018 NEI 5R01EY013433-11 A Ribozyme Rescue Strategy for Autosomal Dominant Retinitis Pigmentosa SULLIVAN, JOHN STATE UNIVERSITY OF NEW YORK AT BUFFALO NY $378,000
Orphan Drug 2018 NIGMS 5R00GM112877-03 Understanding Epstein Barr virus oncogenicity through non-coding RNA structure MOSS, WALTER IOWA STATE UNIVERSITY IA $249,000
Orphan Drug 2018 NIAID 5R21AI127988-02 Targeting Angiogenesis Pathways for Therapeutic Protection against Dengue SHRESTA, SUJAN LA JOLLA INST FOR ALLERGY & IMMUNOLGY CA $225,000
Orphan Drug 2018 NIAID 5R01AI130454-02 Mechanisms of Innate Immune Evasion by Mycobacterium Tuberculosis PHILIPS, JENNIFER WASHINGTON UNIVERSITY MO $567,384
Orphan Drug 2018 NCI 5P30CA008748-52 7554 Animal Imaging LEKAYE, CARL SLOAN-KETTERING INST CAN RESEARCH NY $247,787
Orphan Drug 2018 NCI 5P30CA008748-52 7572 Research Pharmacy MULLER, RAYMOND SLOAN-KETTERING INST CAN RESEARCH NY $206,346
Orphan Drug 2018 NIAID 5R01AI116723-04 Optimization of Antischistosomal Chemotypes VENNERSTROM, JONATHAN UNIVERSITY OF NEBRASKA MEDICAL CENTER NE $598,659
Orphan Drug 2018 NIAID 5R21AI128087-02 Optimizing Gene Editing in Primary Human B Cells for Therapy and Research MORIARITY, BRANDEN UNIVERSITY OF MINNESOTA MN $191,875
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