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RCDC

Project Listing by Category


Back to Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC) Click the column headings to sort project listings.
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CategoryFYFunding ICProject NumberSub Project #Project TitlePI NameOrg NameState / CountryAmount
Orphan Drug 2017 NIAID 1R01AI121054-01 Understanding measles vaccine failure (and success) in Southern India KENNEDY, RICHARD MAYO CLINIC ROCHESTER MN $807,900
Orphan Drug 2017 NINDS 5R01NS087990-04 Intranasal Stem-Cell Based Therapy for Glioblastoma LESNIAK, MACIEJ NORTHWESTERN UNIVERSITY AT CHICAGO IL $405,762
Orphan Drug 2017 NCI 5UM1CA137443-08 Adult Brain Tumor Consortium (ABTC) GROSSMAN, STUART JOHNS HOPKINS UNIVERSITY MD $1,998,892
Orphan Drug 2017 NCI 5R01CA190789-03 Endoplasmic reticulum stress and oncoviral therapy NAWROCKI, STEFFAN UNIVERSITY OF ARIZONA AZ $316,018
Orphan Drug 2017 NIDDK 5R01DK100307-03 Environmental Oxidant Stressors in Pediatric Chronic Kidney Disease - Resubmissio TRASANDE, LEONARDO NEW YORK UNIVERSITY SCHOOL OF MEDICINE NY $636,758
Orphan Drug 2017 NHLBI 4R01HL116533-04 Therapeutic Potential for Aldosterone Inhibition in Duchenne Muscular Dystrophy RAMAN, SUBHA OHIO STATE UNIVERSITY OH $664,132
Orphan Drug 2017 NICHD 5R01HD074944-03 Innovative PK/PD Approaches to Optimize TBM Treatment in Children (PATCH Study) DOOLEY, KELLY JOHNS HOPKINS UNIVERSITY MD $500,491
Orphan Drug 2017 NCI 5R01CA178063-04 Role of beta-catenin in apoptosis resistance of hepatocellular carcinoma RANA, BASABI UNIVERSITY OF ILLINOIS AT CHICAGO IL $331,793
Orphan Drug 2017 NIAMS 5R21AR068040-02 First-in-Human rAAVrh74.MCK.GALGT2 DMD Clinical Trial FLANIGAN, KEVIN RESEARCH INST NATIONWIDE CHILDREN'S HOSP OH $263,120
Orphan Drug 2017 NCI 1K22CA204458-01 Cell survival by anastasis, a novel therapeutic target in cancer TANG, HO LAM JOHNS HOPKINS UNIVERSITY MD $162,000
Orphan Drug 2017 NHLBI 5R44HL114225-03 Mitochondrial DNA repair agents for acute lung injury WILSON, GLENN EXSCIEN CORPORATION KY $1,538,412
Orphan Drug 2017 NINDS 5R01NS093903-03 Metabolic Control of Immune Suppression in Gliomas LESNIAK, MACIEJ NORTHWESTERN UNIVERSITY AT CHICAGO IL $484,938
Orphan Drug 2017 NHLBI 4R44HL129593-02 Preclinical development of inhalable glutaredoxin-1 for the treatment of IPF GUYRE, PAUL CELDARA MEDICAL, LLC NH $750,396
Orphan Drug 2017 NCI 5R01CA178535-05 The contribution of rare alleles to ovarian cancer in the population GAYTHER, SIMON CEDARS-SINAI MEDICAL CENTER CA $549,009
Orphan Drug 2017 NHLBI 5R01HL129887-02 Anti-TB sterilizing immunity in immune and HIV+ individuals CHEN, ZHENG UNIVERSITY OF ILLINOIS AT CHICAGO IL $674,207
Orphan Drug 2017 NCI 5R42CA153845-03 Therapeutic Vaccine Targeting CMV Antigens in Glioblastoma SAMPSON, JOHN ANNIAS IMMUNOTHERAPEUTICS, INC. CA $772,615
Orphan Drug 2017 NHLBI 5R01HL111111-06 Altering Sedation Paradigms to Improve Brain Injury and Survival in Severe Sepsis PANDHARIPANDE, PRATIK VANDERBILT UNIVERSITY MEDICAL CENTER TN $740,946
Orphan Drug 2017 NIAAA 1R01AA025012-01 Epigenetic regulation of alcohol tolerance and dependence by methyl CpG binding protein 2 SANNA, PIETRO SCRIPPS RESEARCH INSTITUTE CA $367,781
Orphan Drug 2017 NIAID 1R43AI122551-01A1 A mucosally targeted MERS-CoV vaccine produced in plants WYCOFF, KEITH PLANET BIOTECHNOLOGY, INC. CA $236,488
Orphan Drug 2017 OD 2U01ES015675-11 Functional Genomics of Chemical-Induced Acute Lung Injury LEIKAUF, GEORGE UNIVERSITY OF PITTSBURGH AT PITTSBURGH PA $442,338
Orphan Drug 2017 OD 5U01ES024097-03 Thioredoxin mimicry: novel treatment of toxicant-mediated inhalational lung injur SOUTHAN, GARRY RADIKAL THERAPEUTICS, INC. MA $781,772
Orphan Drug 2017 NICHD 5U01HD083493-02 Abiraterone Acetate in Childen with Classic 21-Hydroxylase Deficiency WHITE, PERRIN UT SOUTHWESTERN MEDICAL CENTER TX $656,252
Orphan Drug 2017 NHLBI 2P01HL108797-06 8414 Core A: Administrative Core RABINOVITCH, MARLENE STANFORD UNIVERSITY CA $134,248
Orphan Drug 2017 NHLBI 2P01HL108797-06 8418 Clinical Development of Elafin as a PAH Therapy ZAMANIAN, ROHAM STANFORD UNIVERSITY CA $784,522
Orphan Drug 2017 RMAP 5K01ES026832-02 Multi-scale data integration frameworks to improve cancer outcomes ITAKURA, HARUKA STANFORD UNIVERSITY CA $188,952
Orphan Drug 2017 NHLBI 5U01HL121842-02 Phase II Study of AAV9-GAA Gene Transfer in Pompe Disease BYRNE, BARRY UNIVERSITY OF FLORIDA FL $564,323
Orphan Drug 2017 NINDS 1R35NS097275-01 Molecular Genetic Insight into Neurodegenerative Disease from Drosophila BONINI, NANCY UNIVERSITY OF PENNSYLVANIA PA $674,853
Orphan Drug 2017 NINDS 1R35NS097263-01 Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease GITLER, AARON STANFORD UNIVERSITY CA $939,520
Orphan Drug 2017 NCI 1K22CA207598-01 The Role of Suv420h1 Histone Methyltransferase in MYC-Driven Tumorigenesis LI, YULIN METHODIST HOSPITAL RESEARCH INSTITUTE TX $188,379
Orphan Drug 2017 OD 1R56CA198492-01A1 Integrated Nano-Therapeutics to Overcome Tumor Plasticity and Resistance AMIJI, MANSOOR NORTHEASTERN UNIVERSITY MA $299,852
Orphan Drug 2017 NIAID 5R01AI098302-04 Development of a topical malaria vaccine. NARDIN, ELIZABETH NEW YORK UNIVERSITY SCHOOL OF MEDICINE NY $658,790
Orphan Drug 2017 NIAID 5F31AI115931-03 The role of the Unfolded Protein Response in Brucella melitensis replication KHAN, MEKAIL UNIVERSITY OF WISCONSIN-MADISON WI $31,900
Orphan Drug 2017 NHLBI 5R01HL125228-03 Mineralocorticoid receptor and abdominal aortic aneurysm GONG, MING UNIVERSITY OF KENTUCKY KY $519,619
Orphan Drug 2017 NIAID 5R01AI077538-08 The roles of polyphosphate and acidocalcisomes in Trypanosoma brucei DOCAMPO, ROBERTO UNIVERSITY OF GEORGIA GA $375,000
Orphan Drug 2017 NIAMS 2R01AR061370-06 NADPH Oxidase and Autophagic Dysfunction in Duchenne Muscular Dystrophy RODNEY, GEORGE BAYLOR COLLEGE OF MEDICINE TX $348,700
Orphan Drug 2017 NHLBI 5F31HL126462-02 The Role of Long Noncoding RNAs in HbF Variance in Induced Pluripotent Stem Cell-Derived Erythroid Cells from Patients with Sickle Cell Anemia MORRISON, TASHA BOSTON UNIVERSITY MEDICAL CAMPUS MA $28,044
Orphan Drug 2017 NINDS 1R01NS094218-01A1 Focal Sustained Release Chemotherapy-Loaded Biomaterials at Tumor Sites KAPLAN, DAVID TUFTS UNIVERSITY MEDFORD MA $355,019
Orphan Drug 2017 NCI 5R01CA176001-04 Mechanisms of Action for KCN1 in the Control of Uveal Melanoma Metastasis GROSSNIKLAUS, HANS EMORY UNIVERSITY GA $323,700
Orphan Drug 2017 NCI 5R01CA125187-10 Translational Optimization of Bone Regeneration in the Irradiated Mandible BUCHMAN, STEVEN UNIVERSITY OF MICHIGAN MI $244,741
Orphan Drug 2017 NIAID 5R44AI100401-05 Broad Spectrum Antiviral Nucleoside Phosphonate Analogs LIPKA, ELKE TSRL, INC. MI $999,700
Orphan Drug 2017 NCI 5R01CA055349-23 Mechanisms of action of a TCR-like antibody to WT1 SCHEINBERG, DAVID SLOAN-KETTERING INST CAN RESEARCH NY $384,667
Orphan Drug 2017 NHLBI 5R01HL121007-04 Identification and Functional characterization of a gene influencing LDL-C on 5q MITCHELL, BRAXTON UNIVERSITY OF MARYLAND BALTIMORE MD $383,276
Orphan Drug 2017 NCI 1K25CA201545-01A1 Development of microfluidic blood-brain tumor barrier model to screen chemotherapeutic strategies for breast cancer brain metastases LEE, WON JAE STANFORD UNIVERSITY CA $157,167
Orphan Drug 2017 NICHD 5R01HD082127-03 Behavioral Inflexibility in IDD Outcome Measurement BOYD, BRIAN UNIV OF NORTH CAROLINA CHAPEL HILL NC $600,194
Orphan Drug 2017 NIAID 5R01AI075045-08 Resistance of Malaria Parasites to Artemisinin-Based Therapies ROSENTHAL, PHILIP UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $516,182
Orphan Drug 2017 NIAID 5UM1AI069496-11 San Francisco Bay Clinical Trials Unit BUCHBINDER, SUSAN PUBLIC HEALTH FOUNDATION ENTERPRISES CA $1,490,310
Orphan Drug 2017 NIAID 5R01AI104488-04 A Nurse Case Management Intervention to Improve MDR-TB/HIV Coinfection Outcomes FARLEY, JASON JOHNS HOPKINS UNIVERSITY MD $616,042
Orphan Drug 2017 NIAID 5UM1AI069421-11 GHESKIO HIV Clinical Trial Unit PAPE, JEAN GHESKIO CENTER HAITI $1,030,670
Orphan Drug 2017 NIAID 5UM1AI069476-10 The FIOCRUZ Therapeutic and Prevention HIV/AIDS Clinical Trials Unit GRINSZTEJN, BEATRIZ FUNDACAO OSWALDO CRUZ BRAZIL $74,365
Orphan Drug 2017 NCI 5R21CA201453-02 Hyperpolarized arginine imaging of inflammatory cells and their inhibition in GBM RONEN, SABRINA UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $172,369
Orphan Drug 2017 NIDDK 5R01DK066485-10 Structural Basis of KATP Channel Gating SHYNG, SHOW OREGON HEALTH & SCIENCE UNIVERSITY OR $346,500
Orphan Drug 2017 NIGMS 5SC3GM112543-03 Aberrant Epigenetic Repression in Esophageal Malignancy LIN, CHIN-HSING ANNIE UNIVERSITY OF TEXAS SAN ANTONIO TX $103,200
Orphan Drug 2017 NHLBI 5R01HL118390-04 Membrane Serine Protease Activities in Protease Activated Receptor Signaling ANTALIS, TONI UNIVERSITY OF MARYLAND BALTIMORE MD $383,750
Orphan Drug 2017 NIAID 5UM1AI069422-11 South African Medical Research Council Clinical Trials Unit (MRC CTU) RAMJEE, GITA MEDICAL RESEARCH COUNCIL OF SOUTH AFRICA SO AFR $1,084,670
Orphan Drug 2017 NIAID 5UM1AI069418-11 Emory- Duke- Orlando- CDC (EmDOC) Clinical Trials Unit LENNOX, JEFFREY EMORY UNIVERSITY GA $2,403,962
Orphan Drug 2017 NIAID 5R01AI118224-02 Small-Molecule Antibiotics Targeting Siderophore Biosynthesis in M. tuberculosis TAN, DEREK SLOAN-KETTERING INST CAN RESEARCH NY $666,740
Orphan Drug 2017 NIAID 5UM1AI069469-11 CAPRISA Clinical Trials Unit for AIDS/Tuberculosis Prevention and Treatment ABDOOL KARIM, QUARRAISHA CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA SO AFR $1,311,319
Orphan Drug 2017 NIAID 5R01AI118389-03 Vaccines Against Botulism BARBIERI, JOSEPH MEDICAL COLLEGE OF WISCONSIN WI $593,592
Orphan Drug 2017 NIAID 5UM1AI069521-11 Stellenbosch University Clinical Trials Unit (SUN-CTU) COTTON, MARK STELLENBOSCH UNIVERSITY TYGERBERG CAMPUS SO AFR $1,287,739
Orphan Drug 2017 NIAID 5R01AI095309-05 Mucosal live vector vaccine against recurrent Clostridium difficile infections GALEN, JAMES UNIVERSITY OF MARYLAND BALTIMORE MD $383,750
Orphan Drug 2017 NIAID 5R01AI114675-03 A High-Throughput Screen for Antiviral Inhibitors of the Alphavirus RNA Capping Enzyme GEISS, BRIAN COLORADO STATE UNIVERSITY CO $371,750
Orphan Drug 2017 NIAID 5UM1AI069503-11 Terry Beirn CPCRA Clinical Trials Unit GORDIN, FRED GEORGE WASHINGTON UNIVERSITY DC $4,875,952
Orphan Drug 2017 NCI 5R01CA191077-03 Assay Development for NSD1 Methyltransferase Inhibitor Discovery KOLB, EDWARD ALFRED I. DU PONT HOSP FOR CHILDREN DE $312,244
Orphan Drug 2017 NCI 5R21CA194789-02 Novel, orally available ATM inhibitor for glioma conformal radiosensitization VALERIE, KRISTOFFER VIRGINIA COMMONWEALTH UNIVERSITY VA $165,844
Orphan Drug 2017 NCI 5R21CA202487-02 KRAS Muations in Plasma cfDNA as Predictor to Erolinib Response in Advanced Pancreatic Cancer LI, DONGHUI UNIVERSITY OF TX MD ANDERSON CAN CTR TX $174,000
Orphan Drug 2017 NCI 5P30CA014195-44 7749 PL Mouse HUNTER, TONY SALK INSTITUTE FOR BIOLOGICAL STUDIES CA $24,970
Orphan Drug 2017 NIAID 5UM1AI069438-11 IMPACTA PERU CLINICAL TRIALS UNIT LAMA, JAVIER ASOCIACION CIVIL IMPACTA SALUD Y EDUCACN PERU $1,691,063
Orphan Drug 2017 NIAID 5R01AI103280-05 FOSMIDOMYCIN RESISTANCE IN PLASMODIUM FALCIPARUM ODOM, AUDREY WASHINGTON UNIVERSITY MO $342,000
Orphan Drug 2017 NIBIB 5R01EB019458-03 Pre-clinical quantitation of ovarian cancer tumor burden using Magnetic Particle Imaging and non-dilutive cell labeling CONOLLY, STEVEN UNIVERSITY OF CALIFORNIA BERKELEY CA $477,914
Orphan Drug 2017 NINDS 5R21NS091599-02 Stem cell repair after blood brain barrier disruption and high-dose chemotherapy PEARL, MONICA JOHNS HOPKINS UNIVERSITY MD $202,500
Orphan Drug 2017 NIAID 5UM1AI069453-11 KARABELO Clinical Trials Unit for NIAID Networks GRAY, GLENDA WITS HEALTH CONSORTIUM (PTY), LTD SO AFR $1,366,759
Orphan Drug 2017 NCI 5R01CA190617-03 Itraconazole Analogues to Treat Medulloblastoma HADDEN, MATTHEW UNIVERSITY OF CONNECTICUT STORRS CT $382,472
Orphan Drug 2017 NHLBI 5R01HL122068-03 Targeting beta-arrestins in Pulmonary Fibrosis JIANG, DIANHUA CEDARS-SINAI MEDICAL CENTER CA $535,527
Orphan Drug 2017 NCI 1R35CA197695-01A1 Translating genomic discoveries to improved outcomes for high risk acute leukemia MULLIGHAN, CHARLES ST. JUDE CHILDREN'S RESEARCH HOSPITAL TN $1,071,276
Orphan Drug 2017 NIAMS 5R01AR066003-03 MKP5 in Dystrophic Muscle Disease BENNETT, ANTON YALE UNIVERSITY CT $430,920
Orphan Drug 2017 NIAID 5UM1AI069463-11 Clinical Trials Units for NIAID Networks (UM1) SANNE, IAN WITS HEALTH CONSORTIUM (PTY), LTD SO AFR $1,051,232
Orphan Drug 2017 NIAID 5R01AI100569-04 Optimizing ELQs for Treatment and Prevention of Malaria RISCOE, MICHAEL OREGON HEALTH & SCIENCE UNIVERSITY OR $613,423
Orphan Drug 2017 NIAID 5R01AI056312-11 Function of antimalarial drug resistance proteins ROEPE, PAUL GEORGETOWN UNIVERSITY DC $413,757
Orphan Drug 2017 NIAID 5R01AI114685-03 Hit-to-lead discovery for sleeping sickness via industry-academic partnership POLLASTRI, MICHAEL NORTHEASTERN UNIVERSITY MA $521,683
Orphan Drug 2017 NIAID 5R21AI121604-02 Therapeutic Potential of Cystatin 9 Treatment to Fight Bacterial Pneumonia EAVES-PYLES, TONYIA UNIVERSITY OF TEXAS MED BR GALVESTON TX $176,127
Orphan Drug 2017 NCI 5R01CA128943-09 Molecular analysis and therapeutic targeting of PI3K signaling in thyroid cancer DI CRISTOFANO, ANTONIO ALBERT EINSTEIN COLLEGE OF MEDICINE, INC NY $396,625
Orphan Drug 2017 NCI 5F31CA180738-04 Genetic and pharmacological manipulation of system xc in pancreatic cancer BADGLEY, MICHAEL COLUMBIA UNIVERSITY HEALTH SCIENCES NY $44,044
Orphan Drug 2017 NCI 5R01CA190688-02 SON-mediated gene expression and leukemia AHN, ERIN UNIVERSITY OF SOUTH ALABAMA AL $346,556
Orphan Drug 2017 NCI 5R01CA193981-02 KLF9-dependent pathways in multiple myeloma drug resistance NIKIFOROV, MIKHAIL ROSWELL PARK CANCER INSTITUTE CORP NY $392,306
Orphan Drug 2017 NCI 5R01CA194090-02 Treatment of multiple myeloma using oncolytic myxoma virus BARTEE, ERIC MEDICAL UNIVERSITY OF SOUTH CAROLINA SC $341,981
Orphan Drug 2017 NCI 5R01CA195519-02 Image-guided irradiation safely intensifies HSCT regimen for refractory leukemia FORMAN, STEPHEN BECKMAN RESEARCH INSTITUTE/CITY OF HOPE CA $272,213
Orphan Drug 2017 NCI 5R03CA201988-02 Role of Nucleostemin in Conferring The Drug Resistance of Hepatocellular Carcinoma TSAI, ROBERT TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR TX $74,250
Orphan Drug 2017 NCI 5R01CA202919-02 Mechanistic basis and therapeutic strategies for ARID1A mutation in ovarian cancer ZHANG, RUGANG WISTAR INSTITUTE PA $434,625
Orphan Drug 2017 NEI 5R01EY024249-03 A High Content Screening Approach for the Retinal Degenerative Diseases BERLINICKE, CYNTHIA JOHNS HOPKINS UNIVERSITY MD $405,000
Orphan Drug 2017 NEI 5R01EY024906-03 Transcriptional regulation of retinal mitochondrial function and cell cycle POCHE, ROSS BAYLOR COLLEGE OF MEDICINE TX $396,250
Orphan Drug 2017 NIGMS 5R01GM107465-03 Molecular principles of translation termination KOROSTELEV, ANDREI UNIV OF MASSACHUSETTS MED SCH WORCESTER MA $322,438
Orphan Drug 2017 NCI 5R01CA195613-20 Molecular Mechanisms and Therapeutic Approaches to Malignant Gliomas VERMA, INDER SALK INSTITUTE FOR BIOLOGICAL STUDIES CA $671,581
Orphan Drug 2017 NCI 5R01CA199725-02 avb6-directed molecular imaging and therapy SUTCLIFFE, JULIE UNIVERSITY OF CALIFORNIA AT DAVIS CA $488,662
Orphan Drug 2017 NHLBI 5R01HL119960-05 Rituximab Therapy in Patients with IPF DUNCAN, STEVEN UNIVERSITY OF ALABAMA AT BIRMINGHAM AL $682,198
Orphan Drug 2017 NHLBI 5K08HL121182-04 Comparative Effectiveness of N-said Treatment Versus No Treatment for PDA in Pret SLAUGHTER, JONATHAN RESEARCH INST NATIONWIDE CHILDREN'S HOSP OH $153,652
Orphan Drug 2017 NIAID 5R01AI114873-03 ZAP isoforms in innate immunity-the long, the short and the extra-long of it all MACDONALD, MARGARET ROCKEFELLER UNIVERSITY NY $423,750
Orphan Drug 2017 NICHD 5UG1HD083166-03 Collaborative Research to Validate Biomarkers of Pediatric ARDS MCQUILLEN, PATRICK UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $272,314
Orphan Drug 2017 NCI 5R01CA193511-02 NOX4 mediates oxidative stress in ovarian tumor growth and treatment response JIANG, BINGHUA THOMAS JEFFERSON UNIVERSITY PA $356,850
Orphan Drug 2017 NCI 5R01CA194064-03 Combination Therapy of OvCA with Oligonucleotides and Photodynamic Therapy MING, XIN WAKE FOREST UNIVERSITY HEALTH SCIENCES NC $283,650
Orphan Drug 2017 NCI 5R01CA193675-02 Novel Role(s) of Nrf2 in the Growth of Post-Transplantation Cancer PAL, SOUMITRO BOSTON CHILDREN'S HOSPITAL MA $411,185
Orphan Drug 2017 NHLBI 5K24HL111316-05 Forging a road to personalized medicine in interstitial lung diseases FLAHERTY, KEVIN UNIVERSITY OF MICHIGAN MI $181,756
Orphan Drug 2017 NCI 5R01CA193895-02 Glutaminase Inhibitor Drug Discovery and Nanoparticle-Based Delivery for Pancreatic Cancer Therapy SLUSHER, BARBARA JOHNS HOPKINS UNIVERSITY MD $425,618
Orphan Drug 2017 NCI 5R01CA201184-02 Biologic and Therapeutic Significance of miR-155 in AML MARCUCCI, GUIDO BECKMAN RESEARCH INSTITUTE/CITY OF HOPE CA $554,107
Orphan Drug 2017 NCI 5R21CA194836-02 Mouse model to study dependence of pancreatic cancer on Pik3ca for progression LIN, RICHARD STATE UNIVERSITY NEW YORK STONY BROOK NY $169,711
Orphan Drug 2017 NCI 5R01CA142779-07 PD-1/PD-L1 modulation in cancer therapy PARDOLL, DREW JOHNS HOPKINS UNIVERSITY MD $488,332
Orphan Drug 2017 NHLBI 5K23HL119557-03 Improving Pain in Sickle Cell Patients With Targeted Antithrombotic Therapy SHAH, NIRMISH DUKE UNIVERSITY NC $157,929
Orphan Drug 2017 NHLBI 5R01HL071670-14 Arrhythmia Mechanisms in Sarcomeric Cardiomyopathies KNOLLMANN, BJORN VANDERBILT UNIVERSITY MEDICAL CENTER TN $395,000
Orphan Drug 2017 NIAID 5R01AI116605-02 Mechanisms of Mycobacterium Tuberculosis pH-driven Adaptation ABRAMOVITCH, ROBERT MICHIGAN STATE UNIVERSITY MI $380,779
Orphan Drug 2017 NCI 5R01CA168448-05 Next Generation Oncolytic Adenovirus for Advanced Pancreatic Cancer Treatment YAMAMOTO, MASATO UNIVERSITY OF MINNESOTA MN $315,400
Orphan Drug 2017 NCI 5R01CA201719-02 A Novel Positron Emission Tomography Strategy for Early Detection and Treatment Monitoring of Graft-versus-host Disease GAMBHIR, SANJIV STANFORD UNIVERSITY CA $361,504
Orphan Drug 2017 NIDDK 5R01DK107716-02 Regulation of the telomerase RNA component in hematopoiesis AGARWAL, SUNEET BOSTON CHILDREN'S HOSPITAL MA $398,250
Orphan Drug 2017 NICHD 5R00HD073270-05 7-Dehydrocholesterol-derived oxysterols in SLOS: role and therapy XU, LIBIN UNIVERSITY OF WASHINGTON WA $249,000
Orphan Drug 2017 NCI 5R01CA164178-05 A novel NKG2D-specific BiTE cancer immunotherapy SENTMAN, CHARLES DARTMOUTH COLLEGE NH $336,150
Orphan Drug 2017 NCI 5R01CA169784-04 Genetic Dissection of Acute Myeloid Leukemia. AIFANTIS, IANNIS NEW YORK UNIVERSITY SCHOOL OF MEDICINE NY $355,993
Orphan Drug 2017 NCI 5R01CA175380-04 FoxM1 in liver cancer. RAYCHAUDHURI, PRADIP UNIVERSITY OF ILLINOIS AT CHICAGO IL $405,146
Orphan Drug 2017 NCI 5R01CA202846-02 Targeted therapy of peritoneal carcinomatosis using theranostic nanoparticles YANG, LILY EMORY UNIVERSITY GA $411,268
Orphan Drug 2017 NCI 5R01CA190635-03 Genetic Framework and Molecular Mechanism of Fanconi Anemia LI, LEI UNIVERSITY OF TX MD ANDERSON CAN CTR TX $366,000
Orphan Drug 2017 NIMH 5R21MH106793-02 Structural Connectivity Biomarkers in Prodromes and 22q11.2 Deletion Syndrome. KIKINIS, ZORA BRIGHAM AND WOMEN'S HOSPITAL MA $266,250
Orphan Drug 2017 NCI 5R01CA167511-05 Translation of Novel Therapeutic Targets in Multiple Myeloma STEWART, ALEXANDER MAYO CLINIC ARIZONA AZ $431,907
Orphan Drug 2017 NIAID 5R01AI119022-03 Structure and mechanism of the ESX secretion system from pathogenic mycobacteria KOROTKOV, KONSTANTIN UNIVERSITY OF KENTUCKY KY $376,250
Orphan Drug 2017 NCI 5R03CA191443-02 Molecular Mechanisms of Chromosomal Segregation by Epigenetic Regulators REN, XIAOJUN UNIVERSITY OF COLORADO DENVER CO $77,750
Orphan Drug 2017 NIMH 5R01MH106656-02 Disrupted auditory cortical plasticity and behavior in a model of Rett syndrome SHEA, STEPHEN COLD SPRING HARBOR LABORATORY NY $518,964
Orphan Drug 2017 NCI 5R01CA172380-05 Determining the Roles of ATRX and DAXX Abnormalities in Cancer Telomere Biology MEEKER, ALAN JOHNS HOPKINS UNIVERSITY MD $335,820
Orphan Drug 2017 NIAID 5R01AI113266-02 Closing the Gaps on Buruli Ulcer Diagnosis, Treatment, and Prevention NUERMBERGER, ERIC JOHNS HOPKINS UNIVERSITY MD $895,058
Orphan Drug 2017 NIGMS 5R01GM103790-02 Receptor and Carriers for Coupled Ion Transport SESSLER, JONATHAN UNIVERSITY OF TEXAS, AUSTIN TX $300,186
Orphan Drug 2017 NCI 5R01CA189986-03 KSHV alteration of cellular metabolism LAGUNOFF, MICHAEL UNIVERSITY OF WASHINGTON WA $343,260
Orphan Drug 2017 NCI 5F31CA196330-02 Investigating the potential role of NADPH oxidase 2 in regulating the biology of leukemic stem cells ADANE, BINIAM UNIVERSITY OF COLORADO DENVER CO $29,728
Orphan Drug 2017 NIAID 5R21AI115302-02 Self-assembling Peptide Nanomaterials for Eliciting Mucosal CD8+ T cell Immunity RUDRA, JAI UNIVERSITY OF TEXAS MED BR GALVESTON TX $188,800
Orphan Drug 2017 NCI 5R01CA174861-04 Novel Theranostics for Pancreatic Cancer DAVYDOVA, JULIA UNIVERSITY OF MINNESOTA MN $319,031
Orphan Drug 2017 NCI 5R01CA195503-02 Nanoparticle modified Human Fat Derived Mesenchymal Stem Cells for Brain Cancer GREEN, JORDAN JOHNS HOPKINS UNIVERSITY MD $10,280
Orphan Drug 2017 NCI 5R01CA195718-02 Using genetically engineered mouse models of brain tumors to develop therapeutic nanoparticles & biomaterials HOLLAND, ERIC FRED HUTCHINSON CANCER RESEARCH CENTER WA $644,838
Orphan Drug 2017 NIAID 5R01AI103947-05 Lead optimization of DHODH inhibitors for malaria PHILLIPS, MARGARET UT SOUTHWESTERN MEDICAL CENTER TX $595,447
Orphan Drug 2017 NCI 5R01CA181658-03 MRI-Monitored Delivery of Sorafenib-Eluting Microspheres to Liver Tumors LARSON, ANDREW NORTHWESTERN UNIVERSITY AT CHICAGO IL $449,254
Orphan Drug 2017 NCI 5R01CA200624-02 Cytoplasmic Multimerization of the RNA-binding protein HuR is Oncogenic in Glioma NABORS, LOUIS UNIVERSITY OF ALABAMA AT BIRMINGHAM AL $336,380
Orphan Drug 2017 NHLBI 5R01HL130336-02 Targeting Choline Phospholipid Metabolism in Lymphangioleiomyomatosis PRIOLO, CARMEN BRIGHAM AND WOMEN'S HOSPITAL MA $436,000
Orphan Drug 2017 NHLBI 5R01HL130533-02 Identifying Therapeutic Targets for RNA Splicing-Related Cardiomyopathy CONKLIN, BRUCE J. DAVID GLADSTONE INSTITUTES CA $456,506
Orphan Drug 2017 NCI 5R01CA120813-11 Modulation of Microglia and T Cell Interactions in Malignant Glioma HEIMBERGER, AMY UNIVERSITY OF TX MD ANDERSON CAN CTR TX $288,000
Orphan Drug 2017 NCI 5R03CA201502-02 Multiplex 'Conditional' Mice for Rapid and Affordable Pre-clinical Testing MORIARITY, BRANDEN UNIVERSITY OF MINNESOTA MN $76,208
Orphan Drug 2017 NCI 5R01CA194058-02 Painted erythrocyte carriers for therapy of acute myeloid leukemia SIMBERG, DIMITRI UNIVERSITY OF COLORADO DENVER CO $352,151
Orphan Drug 2017 NIGMS 5R01GM113236-03 Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis BESNER, GAIL RESEARCH INST NATIONWIDE CHILDREN'S HOSP OH $338,656
Orphan Drug 2017 NCI 5R01CA190498-03 gp130 as a novel therapeutic target in ovarian cancer NEAMATI, NOURI UNIVERSITY OF MICHIGAN MI $376,320
Orphan Drug 2017 NCI 5R01CA201230-02 The role of H3K79 methylation in IDH-mutant leukemia BERNT, KATHRIN UNIVERSITY OF COLORADO DENVER CO $10,000
Orphan Drug 2017 NIDDK 5R01DK048252-23 Transgene Persistence in Liver Gene Therapy GROMPE, MARKUS OREGON HEALTH & SCIENCE UNIVERSITY OR $368,829
Orphan Drug 2017 NHLBI 5R01HL118312-04 Nanotechnology Approach for Inhalation Treatment of Pulmonary Fibrosis MINKO, TAMARA RUTGERS, THE STATE UNIV OF N.J. NJ $465,656
Orphan Drug 2017 NCI 5R01CA183444-04 Molecular Evaluation of Targeted Therapies in Lymphoid Malignancies BYRD, JOHN OHIO STATE UNIVERSITY OH $523,187
Orphan Drug 2017 NCI 5R21CA187548-02 Second generation MIBG analogs that cotarget DNA for high risk neuroblastoma BARANOWSKA-KORTYLEWICZ, JANINA UNIVERSITY OF NEBRASKA MEDICAL CENTER NE $163,669
Orphan Drug 2017 NEI 5R01EY002422-36 Mechanisms and Therapeutic Treatments for Inherited Retinal Degenerative Diseases MOLDAY, ROBERT UNIVERSITY OF BRITISH COLUMBIA CANADA $267,961
Orphan Drug 2017 NHLBI 5R01HL130974-02 Clinical Genetics and Screening for Pulmonary Fibrosis RABY, BENJAMIN BRIGHAM AND WOMEN'S HOSPITAL MA $876,901
Orphan Drug 2017 NIAID 5R01AI114674-03 The Consequences of Reinfection with M. tuberculosis FLYNN, JOANNE UNIVERSITY OF PITTSBURGH AT PITTSBURGH PA $736,682
Orphan Drug 2017 NIAID 5U01AI115497-03 Placental Colonization by Treponema Pallidum, Congenital Syphilis & Novel Vaccine PARVEEN, NIKHAT RBHS-NEW JERSEY MEDICAL SCHOOL NJ $659,423
Orphan Drug 2017 NCI 5R01CA142665-07 Glucocorticoids in Lymphoblastic Leukemia RELLING, MARY ST. JUDE CHILDREN'S RESEARCH HOSPITAL TN $487,994
Orphan Drug 2017 NCI 7R01CA191222-02 Therapeutic efficacy of the CRL inhibitor MLN4924 in NF2 mutant mesothelioma GIANCOTTI, FILIPPO UNIVERSITY OF TX MD ANDERSON CAN CTR TX $510,996
Orphan Drug 2017 NCI 5R21CA200420-02 The effect of statins on B cell dysfunction in HIV infection MARTINEZ-MAZA, OTONIEL UNIVERSITY OF CALIFORNIA LOS ANGELES CA $215,985
Orphan Drug 2017 NIAID 5R21AI109439-02 T cell driven antigen discovery for vaccine candidates for human Chagas disease PINILLA, CLEMENCIA TORREY PINES INST FOR MOLECULAR STUDIES FL $227,500
Orphan Drug 2017 NHLBI 5R01HL079118-11 Roles of Mre11 in Lymphocyte Development and DNA Repair FERGUSON, DAVID UNIVERSITY OF MICHIGAN MI $381,135
Orphan Drug 2017 NINDS 5R01NS086746-03 NAD, PGC-1alpha and SIRT3 as Therapeutics Targets for Huntington's Disease BEAL, M WEILL MEDICAL COLL OF CORNELL UNIV NY $370,781
Orphan Drug 2017 NIAID 5R21AI121805-02 Towards a new regimen to treat mycobacterial infection in cystic fibrosis patients LAMICHHANE, GYANU JOHNS HOPKINS UNIVERSITY MD $243,000
Orphan Drug 2017 NIAID 5R44AI069631-08 Genetically Attenuated PfSPZ Malaria Vaccine HOFFMAN, STEPHEN SANARIA, INC. MD $999,997
Orphan Drug 2017 NIAID 5R44AI085740-05 In-Vitro Culture of Plasmodium falciparum Sporozoites for Malaria Vaccine HOFFMAN, STEPHEN SANARIA, INC. MD $999,997
Orphan Drug 2017 NIAID 5R21AI117300-02 Development of novel protease inhibitors for influenza and paramyxoviruses WHITTAKER, GARY CORNELL UNIVERSITY NY $234,875
Orphan Drug 2017 NIAID 5R21AI122326-02 Development of Novel Synthetic Alkaloids as Antimalarials CHAKRABARTI, DEBOPAM UNIVERSITY OF CENTRAL FLORIDA FL $201,048
Orphan Drug 2017 NIDCR 5R01DE015648-13 PKCdelta and Salivary Gland Apoptosis REYLAND, MARY UNIVERSITY OF COLORADO DENVER CO $385,531
Orphan Drug 2017 NHLBI 7R01HL130356-02 Molecular mechanism of hypertrophic cardiomyopathy in populations of South Asian descendants SADAYAPPAN, SAKTHIVEL UNIVERSITY OF CINCINNATI OH $405,408
Orphan Drug 2017 NCI 5R01CA080728-17 Dissection of eIF4E dependent mRNA export BORDEN, KATHERINE UNIVERSITY OF MONTREAL CANADA $210,799
Orphan Drug 2017 NCI 5R01CA193556-02 Near infrared intraoperative molecular imaging of lung adenocarcinoma SINGHAL, SUNIL UNIVERSITY OF PENNSYLVANIA PA $674,649
Orphan Drug 2017 NHLBI 5R01HL118068-04 Endothelial Regeneration Following Lung Vascular Injury MALIK, ASRAR UNIVERSITY OF ILLINOIS AT CHICAGO IL $646,129
Orphan Drug 2017 NICHD 5R01HD084500-03 Markers of Disease Progression in MECP2 Duplication Syndrome PETERS, SARIKA VANDERBILT UNIVERSITY MEDICAL CENTER TN $326,662
Orphan Drug 2017 NIAID 5R01AI116665-04 Inhibitors of Purine Import into Plasmodium falciparum Kill Malaria Parasites AKABAS, MYLES ALBERT EINSTEIN COLLEGE OF MEDICINE, INC NY $680,114
Orphan Drug 2017 NCI 5K08CA181340-04 Targeting Chromatin Modifications in Leukemia with Trisomy 21 LANE, ANDREW DANA-FARBER CANCER INST MA $155,991
Orphan Drug 2017 NCI 5P30CA014236-43 5328 Neuro-Oncology Research Program KASTAN, MICHAEL DUKE UNIVERSITY NC $41,908
Orphan Drug 2017 NCI 5P30CA014236-43 5329 Women's Cancer Research Program KASTAN, MICHAEL DUKE UNIVERSITY NC $37,490
Orphan Drug 2017 NCI 5P30CA014236-43 5330 Hematologic Malignancies and Cellular Therapies Research Program KASTAN, MICHAEL DUKE UNIVERSITY NC $41,908
Orphan Drug 2017 NCI 5P30CA014236-43 5331 Solid Tumor Therapeutics Research Program KASTAN, MICHAEL DUKE UNIVERSITY NC $41,908
Orphan Drug 2017 NCI 5R01CA042324-30 Astatine And Iodine Radiolabeled Monoclonal Antibodies ZALUTSKY, MICHAEL DUKE UNIVERSITY NC $455,654
Orphan Drug 2017 NIGMS 5R01GM067871-14 Structural Requirements for Sterol 14alpha-Demethylases LEPESHEVA, GALINA VANDERBILT UNIVERSITY TN $409,128
Orphan Drug 2017 NHLBI 5R01HL070227-14 HL-Development and Pharmacology of novel lipidic rAHF and biotherapeutics BALU-IYER, SATHY STATE UNIVERSITY OF NEW YORK AT BUFFALO NY $395,380
Orphan Drug 2017 NIAID 5R21AI117483-02 Novel Therapeutic Target(s) for Pathogenic Rickettsia Species SAHNI, SANJEEV UNIVERSITY OF TEXAS MED BR GALVESTON TX $193,750
Orphan Drug 2017 NIDDK 5R01DK061659-14 Identifying and Analyzing Genes Linked to Autoimmune Thyroid Diseases TOMER, YARON ALBERT EINSTEIN COLLEGE OF MEDICINE, INC NY $377,138
Orphan Drug 2017 NEI 5R01EY013433-10 A Ribozyme Rescue Strategy for Autosomal Dominant Retinitis Pigmentosa SULLIVAN, JOHN STATE UNIVERSITY OF NEW YORK AT BUFFALO NY $378,000
Orphan Drug 2017 NCI 5R00CA183914-04 A Novel Oncogenic Role for Cdc20 Implications in Adult T Cell Leukemia Treatment WAN, LIXIN H. LEE MOFFITT CANCER CTR & RES INST FL $254,171
Orphan Drug 2017 NIAID 5R21AI121613-02 MITOPlas_Scalable characterization of the malaria parasite mitochondrial proteome NILES, JACQUIN MASSACHUSETTS INSTITUTE OF TECHNOLOGY MA $195,000
Orphan Drug 2017 NHLBI 5R01HL130414-02 Nonsense Readthrough: a Therapeutic Approach to Inherited Vascular Disorders ALDRED, MICHEALA CLEVELAND CLINIC LERNER COM-CWRU OH $396,250
Orphan Drug 2017 NHLBI 5R01HL130871-02 Development of highly efficient factor VIII mini-gene therapy XIAO, WEIDONG TEMPLE UNIV OF THE COMMONWEALTH PA $487,271
Orphan Drug 2017 NIAID 5U01AI112367-03 Safety and efficacy of PfSPZ malaria vaccine in malaria-exposed adults PLOWE, CHRISTOPHER UNIVERSITY OF MARYLAND BALTIMORE MD $870,936
Orphan Drug 2017 NCI 5R01CA047135-27 Merging Marine-Derived Cytotoxic Natural Products With Experimental Therapeutics CREWS, PHIL UNIVERSITY OF CALIFORNIA SANTA CRUZ CA $636,410
Orphan Drug 2017 NCI 5R01CA175772-04 Targeting tumor-stromal interaction for pancreatic cancer therapy SINGH, AJAY UNIVERSITY OF SOUTH ALABAMA AL $314,363
Orphan Drug 2017 NCI 5R01CA190844-03 Hepatic Stellate Cells and Liver Cancer SCHWABE, ROBERT COLUMBIA UNIVERSITY HEALTH SCIENCES NY $356,751
Orphan Drug 2017 NIAID 5R44AI103983-04 A Vaccine for Schistosomiasis, "SchistoShield" CARTER, DARRICK PAI LIFE SCIENCES, INC. WA $1,380,664
Orphan Drug 2017 NIGMS 5R01GM116823-02 Neutrophil-mediated Drug Delivery WANG, ZHENJIA WASHINGTON STATE UNIVERSITY WA $339,750
Orphan Drug 2017 NIAID 5R01AI114304-04 Safety, pharmacokinetics, and resistance to bedaquiline in XDR TB and HIV BRUST, JAMES ALBERT EINSTEIN COLLEGE OF MEDICINE, INC NY $716,766
Orphan Drug 2017 NCI 5F32CA180717-03 The Characterization of the New Tumor Suppressor USP9X in Pancreatic Cancer HWANG, CHANG-IL COLD SPRING HARBOR LABORATORY NY $63,078
Orphan Drug 2017 NIAID 5R21AI121450-02 Analyses of Host Proteins Regulating Alphavirus Genome Function HARDY, RICHARD INDIANA UNIVERSITY BLOOMINGTON IN $191,563
Orphan Drug 2017 NIAID 5R21AI121621-02 The in vivo effect of vitamin D on Mycobacterium tuberculosis infection SALGAME, PADMINI RBHS-NEW JERSEY MEDICAL SCHOOL NJ $189,878
Orphan Drug 2017 NCI 5R01CA203348-02 Blocking NK cell shedding of CD16a to increase cancer cell killing WALCHECK, BRUCE UNIVERSITY OF MINNESOTA MN $444,991
Orphan Drug 2017 NIGMS 5R01GM079656-10 Comparative genomics of protein structure and function LICHTARGE, OLIVIER BAYLOR COLLEGE OF MEDICINE TX $396,958
Orphan Drug 2017 NHLBI 5R01HL122421-02 Mechanisms of Long QT Syndrome 1 in Heart COLECRAFT, HENRY COLUMBIA UNIVERSITY HEALTH SCIENCES NY $442,274
Orphan Drug 2017 NCI 5R01CA196215-02 Systemic Therapy with Infectivity-Selective Oncolytic Adenovirus for PDAC YAMAMOTO, MASATO UNIVERSITY OF MINNESOTA MN $348,844
Orphan Drug 2017 NIAAA 5P50AA011999-19 8467 Functional Dissection of EtOH-med Self-renew of Liver Tumor-Int Cells via TLR4 MACHIDA, KEIGO UNIVERSITY OF SOUTHERN CALIFORNIA CA $206,355
Orphan Drug 2017 NIAID 5R01AI110780-03 Novel Structure-Based Rifamycins for Drug-resistant TB and HIV Co-infection GARCIA, GEORGE UNIVERSITY OF MICHIGAN MI $641,007
Orphan Drug 2017 NCI 5P01CA094237-15 7520 VACCINATION TO ENHANCE T CELL IMMUNOTHERAPY HESLOP, HELEN BAYLOR COLLEGE OF MEDICINE TX $295,519
Orphan Drug 2017 NCI 5P01CA094237-15 7522 ENGINEERING T CELLS FOR PANCREATIC CANCER HESLOP, HELEN BAYLOR COLLEGE OF MEDICINE TX $254,484
Orphan Drug 2017 NCI 5R43CA203351-02 Phase I Clinical trial with 4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) in Children with Cancer Involving the CNS MORGAN, LEE DEKK-TEC, INC. LA $90,362
Orphan Drug 2017 NIAID 1R01AI122070-01A1 A Neonatal Monkey Model for Tuberculosis Vaccination JAGANNATH, CHINNASWAMY UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON TX $903,746
Orphan Drug 2017 NIAID 5R01AI123024-02 Novel methods of pharmacologic monitoring for multidrug resistant tuberculosis treatment in the setting of HIV infection METCALFE, JOHN UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $751,593
Orphan Drug 2017 NIAID 5R01AI093380-05 Malaria Topoisomerase inhibitors RATHOD, PRADIPSINH UNIVERSITY OF WASHINGTON WA $431,121
Orphan Drug 2017 NIAID 5R21AI121831-02 Eating worms: an unusual nicotinic acetylcholine receptor from the nematode pharynx as a potential drug target ROBERTSON, ALAN IOWA STATE UNIVERSITY IA $182,660
Orphan Drug 2017 NCI 5R01CA196631-02 A network platform to connect drug response and prognosis phenotypes for cancers LI, HU MAYO CLINIC ROCHESTER MN $395,911
Orphan Drug 2017 NCI 5R01CA187219-02 Peptide vaccine immunotherapy for children with recurrent low-grade astrocytomas POLLACK, IAN UNIVERSITY OF PITTSBURGH AT PITTSBURGH PA $356,618
Orphan Drug 2017 NCI 5R01CA196263-02 Peripherally-restricted cannabinoids for cancer and chemotherapy-induced pain SCHMIDT, BRIAN NEW YORK UNIVERSITY NY $512,089
Orphan Drug 2017 NIDA 5R01CA196263-02 Peripherally-restricted cannabinoids for cancer and chemotherapy-induced pain SCHMIDT, BRIAN NEW YORK UNIVERSITY NY $75,000
Orphan Drug 2017 NCI 5P30CA023108-38 5370 Cancer Imaging & Radiobiology (CIR) PAULSEN, KEITH DARTMOUTH COLLEGE NH $74,804
Orphan Drug 2017 NCI 5P30CA023108-38 5371 Immunology & Cancer Immunotherapy (ICI) SENTMAN, CHARLES DARTMOUTH COLLEGE NH $74,371
Orphan Drug 2017 NCI 5P30CA008748-51 7554 Animal Imaging LEKAYE, CARL SLOAN-KETTERING INST CAN RESEARCH NY $276,716
Orphan Drug 2017 NCI 5P30CA008748-51 7572 Research Pharmacy MULLER, RAYMOND SLOAN-KETTERING INST CAN RESEARCH NY $239,419
Orphan Drug 2017 NIAID 5R44AI122428-03 Novel therapeutic agent to prevent hearing loss during aminoglycoside therapy GLESER, MALCOLM ORICULA THERAPEUTICS, LLC WA $1,116,932
Orphan Drug 2017 NHLBI 5R01HL121264-04 Endothelialized microfluidics for sickle cell disease research & drug discovery LAM, WILBUR EMORY UNIVERSITY GA $390,164
Orphan Drug 2017 NINDS 5R01NS093704-02 Filamin A in TSC BORDEY, ANGELIQUE YALE UNIVERSITY CT $366,406
Orphan Drug 2017 NCI 5R01CA165469-05 Role of Tcl1 and Par-4 in regulation of chronic lymphocytic leukemia BONDADA, SUBBARAO UNIVERSITY OF KENTUCKY KY $381,420
Orphan Drug 2017 NIBIB 5R01EB020527-03 Radiogenomics Framework for Non-Invasive Personalized Medicine GEVAERT, OLIVIER STANFORD UNIVERSITY CA $503,635
Orphan Drug 2017 NHLBI 5R01HL125926-02 Galectin-3: A mediator of vascular remodeling in pulmonary arterial hypertension FULTON, DAVID AUGUSTA UNIVERSITY GA $538,001
Orphan Drug 2017 NIAID 5R01AI105172-05 Conjugate Anthrax Vaccine with Dual Virulence Factor Specificity GIRI, LALLAN BIOLOGICS RESOURCES, LLC MD $910,923
Orphan Drug 2017 NIAID 5R01AI105204-05 Preclinical characterization of a multivalent killed Filovirus/Rabies vaccine SCHNELL, MATTHIAS THOMAS JEFFERSON UNIVERSITY PA $831,383
Orphan Drug 2017 NIAID 5R01AI118903-03 HOST GENETIC VARIATION REGULATING SALMONELLA INVASION AND DISEASE SUSCEPTIBILITY KO, DENNIS DUKE UNIVERSITY NC $433,415
Orphan Drug 2017 NCI 5R44CA192875-03 FAST TRACK: IND Enabling Studies for Oral Cancer GOLDBERG, MANIJEH PRIVO TECHNOLOGIES, LLC MA $1,170,342
Orphan Drug 2017 NCI 5R03CA201960-02 Development of multifunctional biodegradable drug-loaded polymer stents for inoperable esophageal malignancies KANG, YUNQING FLORIDA ATLANTIC UNIVERSITY FL $70,772
Orphan Drug 2017 NCATS 1R21TR001743-01 Targeting glucose metabolism for the treatment of Hepatocellular Carcinoma CHEN, BIN UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CA $292,022
Orphan Drug 2017 NIAID 5R01AI116155-03 Pharmacometric optimization of second line drugs for MDR tuberculosis treatment MCILLERON, HELEN UNIVERSITY OF CAPE TOWN SO AFR $245,442
Orphan Drug 2017 NIAID 5R01AI117017-03 Chemogenomic Profiling of Plasmodium falciparum Drug Responses and Resistance ADAMS, JOHN UNIVERSITY OF SOUTH FLORIDA FL $715,282
Orphan Drug 2017 NIAID 5R01AI118305-03 MicroRNA Regulates Graft-versus-Host Disease YU, XUE-ZHONG MEDICAL UNIVERSITY OF SOUTH CAROLINA SC $371,988
Orphan Drug 2017 NCI 5R01CA184088-03 Liposomal Doxorubicin and Pluronic Combination for Cancer Therapy KABANOV, ALEXANDER UNIV OF NORTH CAROLINA CHAPEL HILL NC $344,549
Orphan Drug 2017 NCI 5R01CA166144-06 Development of Therapeutic CD59 inhibitor for treating B-cell malignancies QIN, XUEBIN TEMPLE UNIV OF THE COMMONWEALTH PA $327,938
Orphan Drug 2017 NCI 5R21CA183623-03 Pediatric Cancer Salvia Biorepository GRAHAM, DAVID JOHNS HOPKINS UNIVERSITY MD $245,885
Orphan Drug 2017 NIBIB 5R00EB016690-04 Role of cerebrospinal fluid dynamics in brain drug delivery SY, JAY RUTGERS, THE STATE UNIV OF N.J. NJ $243,727
Orphan Drug 2017 NIAID 5R01AI051334-14 Extracellular Matix Adhesins of Treponema pallidum CAMERON, CAROLINE UNIVERSITY OF VICTORIA CANADA $232,650
Orphan Drug 2017 NIAID 5R01AI108819-05 Characterization of isoprenoid biosynthesis in human malaria gametocytes CASSERA, MARIA UNIVERSITY OF GEORGIA GA $375,000
Orphan Drug 2017 NIAID 5F30AI114070-03 Dissecting the molecular basis of PfCRT-mediated antimalarial drug resistance GABRYSZEWSKI, STANISLAW COLUMBIA UNIVERSITY HEALTH SCIENCES NY $44,044
Orphan Drug 2017 NHLBI 5R00HL118157-04 Regulation of Erythroid Terminal Differentiation by Long Noncoding RNAs HU, WENQIAN MAYO CLINIC ROCHESTER MN $249,000
Orphan Drug 2017 NHLBI 5R01HL114770-05 Functional consequences of FHC mutations in cardiac MyBPC STELZER, JULIAN CASE WESTERN RESERVE UNIVERSITY OH $396,250
Orphan Drug 2017 NIAID 5R21AI123984-02 Targeting intrinsic resistance to combat multi-drug resistant P. aeruginosa KAZMIERCZAK, BARBARA YALE UNIVERSITY CT $250,575
Orphan Drug 2017 NIA 5R01NS095969-02 TDP-43 Proteinopathy in ALS-FTD: Mechanism, Target Validation and Biomarker WONG, PHILIP JOHNS HOPKINS UNIVERSITY MD $50,625
Orphan Drug 2017 NINDS 5R01NS095969-02 TDP-43 Proteinopathy in ALS-FTD: Mechanism, Target Validation and Biomarker WONG, PHILIP JOHNS HOPKINS UNIVERSITY MD $354,375
Orphan Drug 2017 NIAID 5R21AI122001-02 A Clinical Pharmacology Study of a Novel Drug Regimen for Pre XDR and XDR Tuberculosis KEMPKER, RUSSELL EMORY UNIVERSITY GA $193,545
Orphan Drug 2017 NIAID 5R01AI123244-02 Mucosal Vaccines for Brucellosis PASCUAL, DAVID UNIVERSITY OF FLORIDA FL $375,000
Orphan Drug 2017 NCI 5R01CA183984-03 A novel miR-198 replacement therapy for pancreatic cancer YAO, QIZHI BAYLOR COLLEGE OF MEDICINE TX $473,915
Orphan Drug 2017 NIDCR 5R21DE025732-02 SULF2 in HNSCC GOLDMAN, RADOSLAV GEORGETOWN UNIVERSITY DC $194,375
Orphan Drug 2017 NIAID 5R01AI110478-04 Innovative partnership to target antimalarial subsidies in the retail sector PRUDHOMME-O'MEARA, WENDY DUKE UNIVERSITY NC $474,165
Orphan Drug 2017 NIAMS 5R01AR044345-19 Genes and Therapies for Centronuclear Myopathies BEGGS, ALAN BOSTON CHILDREN'S HOSPITAL MA $369,750
Orphan Drug 2017 NCI 5P01CA055791-23 5790 Core B: Optics FOSTER, THOMAS UNIVERSITY OF ROCHESTER NY $72,254
Orphan Drug 2017 NCI 5P01CA055791-23 5793 Project 1: PDT of HNSCC BIEL, MERRILL ROSWELL PARK CANCER INSTITUTE CORP NY $190,533
Orphan Drug 2017 NCI 5P01CA055791-23 5795 Project 3: Immune Response to PDT GOLLNICK, SANDRA ROSWELL PARK CANCER INSTITUTE CORP NY $125,626
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